Expert prediction
NFL Week 4: Chargers vs. Giants Preview, Odds, Picks (Sep 28)
- Nikola Velickovic
- Sep 23, 2025 at 12:18 PM EDT
Pick rationale
Analysis & key factors
- Chargers vs. Giants game is broadcast on CBS.
- Chargers allowed just 4 touchdowns in the opening three games.
- Giants allow 405.3 yards per game, which is the 2nd worst in the NFL.
Giants host another AFC West team now. After the Chiefs, their next rivals are the LA Chargers.
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How to Watch
- When: Sunday, September 28, 1 pm ET
- Where: MetLife Stadium, East Rutherford, New Jersey
- How to Watch: CBS
Chargers vs. Giants Odds
Game Preview
The Chargers are 3-0 so far, with them beating the Broncos last Sunday, 23-20, with the kicker Cameron Dicker hitting a 43-yard field goal with the time expiring. They’ve limited the Broncos to just 9 first downs, but two turnovers were what slowed down Jim Harbaugh’s unit.
Herbert threw for 300 yards, one touchdown, and one pick, and was sacked 5 times. But in the crucial moments, he rose to the occasion and delivered, showing his worth. RB Omarion Hampton ran for 70 yards and a TD, while Keenan Allen caught one TD too.
There’s a lot of bandwagon Justin Herbert support lately. What I mean by that, is they’re exposing themselves by saying he’s “finally clutch” etc.
— BoltzGalaxy⚡️🪐 (@boltzgalaxy) September 22, 2025
The real Chargers fans have known….. 😴#BoltUp pic.twitter.com/T9aAIE1Owg
The New York Giants met the Chiefs in Sunday Night Football and lost 22-9. Russell Wilson had another bad game, throwing for two interceptions and just 160 yards. Maybe it’s time for him to be a backup, rather than a starter.
Giants have the second-worst defense in the league in yards allowed, with 450.3. Rivals post 153.3 rushing yards, and we are more than sure that Harbaugh already plans to overload that part of the Giants’ defense.
Chargers vs. Giants Head to Head
The Chargers have 8 wins, and the Giants have 5, but the franchise from LA has posted 5 wins in a row.
Chargers vs. Giants Predictions
Whoever starts for the Giants will have a tough challenge, because one of the best NFL defenses is across the field. Now, even though RB Najee Harris is probably out for this event, the Chargers still have a better team, and we pick them to win.
- Free NFL picks: Chargers win
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