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Expert prediction

NFL Week 5: Commanders vs. Chargers Preview, Odds, Picks (Oct 5)

  • Nikola Velickovic
  • Oct 1, 2025 at 5:23 AM EDT

Pick rationale

Analysis & key factors

  • Commanders vs. Chargers game total is 47.5 points.
  • Washington Commanders QB Jayden Daniels is likely to play on Sunday.
  • LA Chargers allow 17.8 points per game

The good news for the Commanders is that Jayden Daniels is expected to return in Week 5, which significantly boosts the morale of his team. But on the other side, one of the toughest NFL defenses awaits him.

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How to Watch

  • When: Sunday, October 5, 4:25 pm ET
  • Where: SoFi Stadium, Los Angeles, California
  • How to Watch: FOX

Commanders vs. Chargers Odds

TeamMoneylineSpreadTotals
Commanders+135+2.547.5
Chargers-155-2.547.5

Game Preview

Washington lost to the Falcons in Atlanta, 34-27. They would fumble the ball four times and looked unfocused in the crucial moments of the event, which is why they ended up on the losing side after the clock expired.

Though with Daniels, they should be better. He is one of the best dual-threat QBs in the league, and the guy who creates plays all by himself. Plus, he has an elite receiving core, Samuel, McLaurin, and Ertz.

The Chargers lost at home to the Giants, 21-18, in what appeared to be the biggest surprise of the entire round. Justin Herbert was picked off twice, and he ended the game with just 203 passing yards and 23 completions in 41 attempts.

Jim Harbaugh’s boys allowed 161 rushing yards, which is unusual, considering this team has one of the best defenses in the league. Also, we have to admit that the Chargers covered up Najee Harris’ absence well, as RB Omarion Hampton stepped in to generate 128 rushing yards and a touchdown.

Commanders vs. Chargers Head to Head

After a dozen games played, the Commanders have a 7-5 edge over the Chargers.

Commanders vs. Chargers Predictions

Washington has more than enough options in the attack, but this game will be tough, especially because the Chargers need to react following last week’s surprise. Therefore, we pick under 47.5 points, which is the total for this event.

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