Expert prediction
NFL Week 9: Chiefs vs. Bills Preview, Odds, Picks (Nov 2)
Pick rationale
Analysis & key factors
- Chiefs vs. Bills is the Week 9 top game.
- The Kansas City Chiefs are 2.5-point favorites.
- The total for this game is set at 52.5 points.
Once again, Patrick Mahomes and Josh Allen meet as their Chiefs and Bills lock horns in the NFL Week 9. This should be an interesting and very enjoyable clash.
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How to Watch
- When: Sunday, November 2, 8:25 pm ET
- Where: Highmark Stadium, Orchard Park, New York
- How to Watch: CBS
Chiefs vs. Bills Odds
Game Preview
The Chiefs are rolling again, having three straight wins. Though they played at home in all of these events, and this comes as a big test for Mahomes and the boys, who are 5-3 right now.
Believe it or not, the Chiefs allow 16.4 points per game, which is the second fewest in the league, and limit the rivals to only 177.8 passing yards, the 3rd best in the NFL. This is something we don’t discuss too often, largely due to Mahomes and the offense. Therefore, credit to the KC’s defense.
As for the Bills, they sit at 5-2, but need to win here because the Pats are after the top seed in the AFC East. Allen and the guys are finally back home, following back-to-back matches on the road, a loss to the Falcons 24-14, and a win in Carolina, 40-9.
Their secondary is fantastic, and Buffalo allows only 161.9 passing yards per game; however, on the other hand, they are the worst run defense in the NFL, allowing 150.3 rushing yards per game. Now, that’s a weakness they’ll have to eliminate.
Chiefs vs. Bills Head to Head
Bills lead the series, 30-26-1. Since 2021, we have seen them play 4 times in the playoffs, and each time, Mahomes has eliminated Allen. Most recently, in 2025, when they clashed in the AFC Championship Game, 32-29. Although the Bills have had more success in the regular season during this span, the playoffs are what truly matter.
Chiefs vs. Bills Predictions
When these teams meet, what can you do but bet on Over? The line here is 52.5 points, and that’s what we’re taking. When these teams met, they usually played efficient matches, and we rarely saw under 50 points.
- Free NFL Picks: Over 52.5 points
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