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Expert prediction

MLS: LA Galaxy vs. St. Louis City SC Preview, Odds, Predictions (Jul 22)

  • Nikola Velickovic
  • Jul 19, 2026 at 5:49 AM EDT

Pick rationale

Analysis & key factors

  • LA Galaxy vs. St. Louis City odds favor the hosts at -205.
  • Both teams fight for the playoffs.
  • St. Louis never lost to Galaxy in an MLS fixture.

After losing to LAFC in El Trafico, Galaxy will try to bounce back against St. Louis City.

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How to Watch

  • When: Wednesday, July 22, 10:30 PM ET
  • Where: Dignity Health Sports Park, Carson, California
  • How to Watch: Apple TV, MLS Season Pass

LA Galaxy vs. St. Louis City SC Odds

TeamOdds
LA Galaxy-105
Tie+285
St. Louis City+260

Match Preview

LA Galaxy lost El Trafico 3-0 last Friday, and that’s surely a painful way to restart the MLS season following a month-long pause. From what we saw in that event, the Galaxy’s defense looks very fragile, yet, that’s nothing new for this unit.

The team from LA has allowed 25 goals so far, and has one of the worst defenses in the West. To be precise, 5th worst in the conference. That’s the reason why Galaxy isn’t in the playoff zone right now.

St. Louis has a positive momentum. They beat Sporting Kansas City on Thursday, 3-2, picking up where they left off before the break. Yoann Damet and his crew now have 6 consecutive matches without a loss.

Though, when playing as guests, St. Louis isn’t good at all. They have one win in 8 road trips with 3 ties and 4 defeats. Also, their goal difference is pretty poor, 5-13.

LA Galaxy vs. St. Louis City SC Head to Head

There was a friendly between these two teams in February, where Galaxy won 3-0. But prior to that, St. Louis didn’t lose to Galaxy in 6 consecutive MLS fixtures.

LA Galaxy vs. St. Louis City SC Predictions

Galaxy has to bounce back, and this game is very important to them because it’s against their direct playoff rivals. Since the guests from St. Louis aren’t good on the road, and Galaxy has the imperative to win and plays at home, we are going to pick the unit from LA to triumph.

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