MLS Predictions: Best Bets, Odds & Weekend Picks (Sep 12-13)

The penultimate round of matches in the MLS before the September international break are set for across North America this weekend. There will be pressure on a couple of teams to bounce back to form in their aim to finish in a playoff spot, with Inter Miami and Nashville colliding across the weekend of September 12-13.

LAFC will also be in action when they travel to Sporting KC, while FC Dallas and Portland meet in Texas. Below, you can find a complete breakdown of our top betting angles for the upcoming weekend, identifying value plays to follow at the best soccer sportsbooks and key MLS picks.

MLS Best Bets & Top Value Picks

• Best Pick: Columbus Crew (vs. New York Red Bulls)
• Best Both Teams to Score (BTTS): St. Louis SC vs. Minnesota United
• Top Value Over/Under: Inter Miami vs. Nashville (Over 2.5 Goals)

Key Fixture Breakdown & Predictions

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Inter Miami vs. Nashville SC Prediction & Odds

Kickoff: Saturday, September 12 | Nu Stadium, Miami

Match Preview

The standout matchup in the MLS this weekend comes from the Eastern Conference as the top two collide at Nu Stadium. Inter Miami are winless in two outings since beating Montreal 7-1, as they have played out successive draws against Atlanta United and Chicago. That has allowed Nashville to move nine points clear at the summit, despite a recent loss on the road against Toronto FC. The Coyotes recorded a dominant 4-1 win against Inter last month, but it could be a different story this weekend based on Inter’s excellent home record. Therefore, a chance could be taken on Miami to record the victory required to close the gap between the sides at the Eastern summit.

• Best Bet: Inter Miami (-129)

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Orlando City vs. Toronto FC Prediction & Odds

Kickoff: Saturday, September 12 | Inter&Co Stadium, Orlando

Match Preview

A crucial matchup in the contest of the Eastern Conference playoff race is set for Inter&Co Stadium on Saturday, as in-form Orlando City bid to strengthen their spot in the top seven. City have recorded back-to-back wins against Atlanta and San Diego, but their defensive weakness is a major concern, having allowed five goals in their previous three. Toronto FC’s confidence will be sky-high following an excellent win against Nashville last Saturday, meaning that they have now avoided defeat in their last seven. However, the fact that three of their previous five have ended in draws could pinpoint an area of value when making MLS picks.

• Best Bet: The Draw (+310)

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San Jose vs. Houston Dynamo Prediction & Odds

Kickoff: Saturday, September 12 | PayPal Park, San Jose

Match Preview

Two of the top five in the Western Conference collide at PayPal Park on Saturday. San Jose have avoided defeat in their previous three, but their only victory over that period was recorded last time out against San Diego. Houston have lost just once in their previous eight, but they ended a three-game winless run against Real Salt Lake in midweek. Houston’s efficiency on their travels this season could prove to be a notable angle when making picks this weekend, and it is also notable that the Dynamo have won three of their last six against San Jose. Over that period, Houston have lost just once.

• Best Bet: Houston Dynamo (+187)

MLS Best Parlay Pick

A parlay could be an excellent way to enhance returns on favored selections in the MLS this weekend. The Vancouver Whitecaps and Columbus Crew both boast excellent home records, and both are expected to continue their reliable form this week. Inter Miami could be a value inclusion based on their world-class attacking talent. Meanwhile, LAFC rounds off our MLS parlay picks when they come up against a struggling Sporting KC.

MLS Parlay Pick: Inter Miami, LAFC, Columbus Crew & Vancouver Whitecaps All to Win (+545)