MLS Predictions: Best Bets, Odds & Weekend Picks (Sep 18-20)

The MLS action continues to come thick and fast, as the end of the regulation season continues to get closer. There will be a full round of matches this coming weekend, with notable clashes seeing New York rivals, City and the Red Bulls, colliding on Friday evening.

Meanwhile, LAFC will be aiming to bounce back to winning ways when they travel to the San Jose Earthquakes in the Western Conference. You can find our best bets, value plays, and MLS picks for the coming round of matchups this weekend here.

MLS Best Bets & Top Value Picks

• Best Pick: Inter Miami (vs. San Diego FC)
• Best Both Teams to Score (BTTS): New England Revolution vs. Orlando City
• Best Value Over/Under: Portland Timbers vs. Atlanta United Over 2.5

ALSO SEE: Presidents Cup Picks, Odds & Betting Preview (Sep 24-27)

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Key Fixture Breakdown & Predictions

San Jose Earthquakes vs. LAFC Prediction & Odds

Kickoff: Saturday, September 19 | PayPal Park, San Jose

Match Preview

There will be slight pressure on LAFC to bounce back to form this weekend, as the Californian franchise have dropped to sixth in the Western Conference standings following a run of just one win in seven. Last weekend, LAFC suffered a damaging 3-1 road loss against Sporting KC, meaning that they have now failed to win in five on the road.

San Jose have gone in the opposite direction in the West, winning back-to-back encounters and avoiding defeat in four to rise up to fourth in the standings. The Earthquakes could be the interesting selection when making MLB betting picks this weekend, as they have won seven of their last ten against LAFC at PayPal Park.

• Best Bet: San Jose Earthquakes (+190)

New England Revolution vs. Orlando City Prediction & Odds

Kickoff: Saturday, September 19 | Gillette Stadium, New England

Match Preview

An interesting clash in the Eastern Conference playoff race is set for Saturday, as Orlando City travel to Gillette Stadium to take on the New England Revolution. The Revs have been in consistent recent form, winning back-to-back encounters and claiming three victories in their last four.

Meanwhile, Orlando City have won three straight matches in the MLS. However, the prowess of New England at Gillette Stadium could ensure that the hosts are the standout selection when making MLB betting picks. The Revs have won eight of their 12 home matches this season, conceding just 0.92 goals per 90.

• Best Bet: New England Revolution (-116)

New York City FC vs. NY Red Bulls Prediction & Odds

Kickoff: Friday, September 18 | Yankee Stadium, New York

Match Preview

This weekend’s round of MLS matches is headlined by the Hudson River Derby. The NY Red Bulls will have their sights set on back-to-back wins in the MLS following a much-needed victory against Columbus last time out.

That victory ended a run of two defeats in three. NYCFC also ended a winless run last time out, landing a success against Real Salt Lake to snap a seven-game wait for a win in the MLS. NYCFC have dominated the recent Derby matches, winning three of the previous four. That could be a trend worth following when making MLS betting picks on Friday.

• Best Bet: NYCFC (-132)

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MLS Best Parlay Pick

Significant returns could be achieved when making selections on an MLS parlay this weekend. Banker legs for the parlay will include Inter Miami and St. Louis City, who both bring reliable form into the round of matches. The Portland Timbers could also take advantage of home-field advantage. Value selections include the Vancouver Whitecaps and Philadelphia Union, who will be on the road this weekend against Real Salt Lake and Sporting KC, respectively.

• Best MLS Parlay Bet: Inter Miami, St. Louis City, Portland Timbers, Vancouver Whitecaps & Philadelphia Union All To Win (+1448)