MLS Predictions: Best Bets, Odds & Weekend Picks (Sep 26-27)

The MLS action rolls on this weekend, despite many of the leading teams being without key stars due to the October international break. Fascinating clashes are set for across the Eastern and Western Conferences, which includes a showdown between Nashville and Toronto at Geodis Park, and LAFC’s trip to FC Dallas. You can find our MLS predictions, best bets, and picks for this weekend here.

MLS Best Bets & Top Value Picks

• Best Pick: Nashville SC (vs. Toronto FC)
• Best Both Teams to Score (BTTS): Columbus Crew vs. Inter Miami CF
• Best Value Over/Under: LA Galaxy vs. Colorado Rapids Over 2.5

ALSO SEE: Presidents Cup Picks, Odds & Betting Preview (Sep 24-27)

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Key Fixture Breakdown & Predictions

Austin vs. San Diego Prediction & Odds

Kickoff: Saturday, September 26 | 8:30 PM ET | Q2 Stadium, Austin

Match Preview

The pressure intensifies on the teams in the hunt for Western Conference playoff spots in the MLS this week, as a highlight clash will see San Diego travel to Austin.

The hosts bring reliable form into this weekend’s clash, as they have avoided defeat in their last five fixtures since losing in the Leagues Cup against Toluca. However, Austin have played out draws in their previous three at Q2 Stadium. San Diego will be vulnerable on the road this weekend, having failed to win in their last four in the MLS, losing on three occasions over that period.

• Best Bet: Austin (+144)

Philadelphia Union vs. Orlando City Prediction & Odds

Kickoff: Saturday, September 26 | 7:30 PM ET | Subaru Park, Philadelphia

Match Preview

The Philadelphia Union are the in-form team in the Eastern Conference, and they will be aiming to close the gap on the teams at the top of the standings when they host Orlando City on Saturday.

Philadelphia have recorded victories in each of their previous five fixtures, scoring an incredible 14 goals in their previous three. Orlando should have the attacking quality to hurt the Union this week, having scored five in their previous two in the MLS. However, when making MLS picks this weekend, the Union are incredibly hard to oppose after avoiding defeat in nine of their 12 at Subaru Park in 2026.

• Best Bet: Philadelphia Union (-230)

Columbus Crew vs. Inter Miami Prediction & Odds

Kickoff: Sunday, September 27 | 7:00 PM ET | ScottsMiracle-Gro Field, Columbus

Match Preview

The Columbus Crew will be in action for the first time since dismissing Federico Higuain when they take on Inter Miami on Sunday. The Crew have won back-to-back games in the MLS, and they have shown defensive strength with clean sheets in two of their last five in all competitions.

Inter Miami’s consistency is a major concern this week, as they have played out draws in their previous four. The fact that their weak defensive record has seen them allow seven goals over that period can’t be overlooked. Therefore, this looks like a good opportunity for the Crew to enhance their playoff credentials.

• Best Bet: Columbus Crew (+175)

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MLS Best Parlay Pick

An MLS parlay pick could enhance the returns achieved by a bettor this weekend. As mentioned above, the Philadelphia Union should be capable of extending their excellent record.

Meanwhile, home victories for Nashville, Vancouver, and Charlotte FC will add value to the wager. The Crew will round off our 5-leg parlay this week against a leaky defensive rival in the form of Inter Miami.

• Best MLS Parlay Bet: Philadelphia Union, Nashville SC, Vancouver Whitecaps, Charlotte FC & Columbus Crew All To Win (+1455)

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Best Bets For All MLS Matches This Weekend

Date	Time	Fixture	MLS Pick
Sat, Sep 26	7:30 PM ET	NY Red Bulls vs. St. Louis	BTTS (Both Teams to Score)
Sat, Sep 26	7:30 PM ET	Philadelphia vs. Orlando City	Philadelphia
Sat, Sep 26	7:30 PM ET	Atlanta vs. NYCFC	Over 2.5 Goals
Sat, Sep 26	7:30 PM ET	Montreal vs. Cincinnati	FC Cincinnati
Sat, Sep 26	7:30 PM ET	Charlotte vs. Chicago	Charlotte FC
Sat, Sep 26	8:30 PM ET	Austin vs. San Diego	BTTS (Both Teams to Score)
Sat, Sep 26	8:30 PM ET	Houston vs. Sporting KC	Houston
Sat, Sep 26	8:30 PM ET	Dallas vs. LAFC	BTTS (Both teams to Score)
Sat, Sep 26	8:30 PM ET	Nashville vs. Toronto	Nashville
Sat, Sep 26	8:30 PM ET	Seattle vs. Minnesota	Seattle
Sat, Sep 26	9:30 PM ET	Salt Lake vs. New England	Over 2.5 Goals
Sat, Sep 26	10:30 PM ET	Vancouver vs. D.C. United	Vancouver
Sat, Sep 26	10:30 PM ET	LA Galaxy vs. Colorado	LA Galaxy
Sat, Sep 26	10:30 PM ET	San Jose vs. Portland	BTTS (Both Teams to Score)
Sun, Sep 27	7:00 PM ET	Columbus vs. Inter Miami	Over 2.5 Goals