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Expert prediction

NFL Preseason Week 1: Giants vs. Bills Preview, Odds, Picks (Aug 9)

  • Nikola Velickovic
  • Aug 2, 2025 at 7:27 AM EDT
  • Giants vs. Bills odds favor Buffalo by 2.5 points.
  • Brian Daboll is under heavy pressure.
  • This is a crucial season for Laviska Shenault’s career.

Plenty is going on in both the Giants and the Bills, and this game is important for both sides. For the Giants’ HC Brian Daboll, more than anyone thinks.

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How to Watch

  • When: Saturday, August 9, 1 pm ET
  • Where: Orchard Park, NY, NY
  • How to Watch: NFL Net

Giants vs. Bills Odds

TeamMoneylineSpreadTotals
Giants+110+2.535.5
Bills-130-2.535.5

Giants vs. Bills Predictions

It seems that Brian Daboll doesn’t have too much time. His Giants have to show something at the start of the season; otherwise, he will be fired. Daboll is already one of the top favorites for being the first NFL head coach fired this season.

Jaxson Dart and Jameis Winston are about to lock their horns for the backup QB spot. This is important because Russell Wilson may just lose his grip on the starting position. So whoever wins here has realistic chances of becoming the starter at some point in the campaign.

Meanwhile, Mitch Trubisky is the backup in Buffalo. However, we think Mike White and Shane Buechele will get some reps here. They must be prepared in case anything unexpected happens.

Our focus here is on WR Laviska Shenault. One of the biggest talents when entering the league faded, and this is his last chance to regain some consistency and hopefully earn his spot under the NFL sun.

Giants vs. Bills Head to Head

The Bills won the last game in 2023, 14-9, and they lead the all-time series, 8-7.

Giants vs. Bills Prediction

Giants backup QBs are far better than the Bills’, and that’s the sole reason why we pick the guests to win. Additionally, we believe that Sean McDermott will utilize replacements and those trying to secure a spot on the final roster, while Daboll must develop chemistry among his top players during the preseason.

  • Free NFL picks: Giants win
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