Expert prediction
NFL Week 1: Chiefs vs. Chargers Preview, Odds, Picks (Sep 5)
- Nikola Velickovic
- Aug 28, 2025 at 3:31 AM EDT
- Chiefs vs. Chargers clash is set for Friday night in Sao Paulo.
- Kansas City is a 3.5-point favorite.
- The Chargers had the best defense in the NFL last year.
Another divisional rivalry will highlight the start of the season. Patrick Mahomes and the Chiefs visit Justin Herbert and the Chargers in LA.
If you are interested in more NFL odds and predictions, follow this link.
How to Watch
- When: Friday, September 5, 8:00 pm ET
- Where: Corinthians Arena, Sao Paulo, Brazil
- How to Watch: YouTube
Chiefs vs. Chargers Odds
Game Preview
The Chiefs had a season in which they oscillated too much, which is the reason why they haven’t reached the Super Bowl. Still, they have one of the best teams in the NFL and are among the top contenders for winning the Vince Lombardi trophy.
To be better this year, they’ll need to get TE Travis Kelce back on track. After deciding to marry Taylor Swift, the strong tight end should sort his stats out, as he had only 823 receiving yards last year, his worst since becoming a starter.
S/O to the Chargers for the opportunity 🙏🏽🙏🏽🙏🏽 Keep Chopping DJ ‼️ pic.twitter.com/hH1nMruY1k
— Big Dave Uiagalelei (@DUiagalelei) August 27, 2025
The Chargers’ defense allowed 17.7 points last year and was ranked No.1 in the NFL. Though, there were some changes this offseason that saw several players leaving LA, among them Joey Bosa.
On the flip side, RB Najee Harris landed in California, and knowing his characteristics, the LAC got one hard-working grinder who will constantly attack defensive lines.
Chiefs vs. Chargers Head to Head
The Chiefs hold an edge in the all-time series, with 71 wins, while the Chargers have 58 triumphs. One game saw a tie. Right now, Kansas City has 7 triumphs in a row over the Chiefs.
Last year, we saw their victories, 17-10 in LA and 19-17 at home.
Chiefs vs. Chargers Predictions
The over/under line is set at 46.5 points, and even though the Chargers lost plenty of their defensive stars, we are still going with under here. After all, Jim Harbaugh wouldn’t have let them go without having a proper replacement in position.
Free NFL picks: Under 46.5 points
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NNikola Velickovic 3 min read
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
NNikola Velickovic 2 min read
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
NNikola Velickovic 2 min read
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
NNikola Velickovic 2 min read
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]
NNikola Velickovic 2 min read