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Expert prediction

NFL Week 1: Cardinals vs. Saints Preview, Odds, Picks (Sep 7)

  • Nikola Velickovic
  • Aug 30, 2025 at 4:21 AM EDT
  • Cardinals vs. Saints odds favor Arizona by 6.5 points.
  • Spencer Rattler has been named as the New Orleans Saints’ starting QB.
  • The total for this game is 42.5 points.

The Arizona Cardinals looked strong during the preseason, and they have high expectations for this season. Meanwhile, the Saints didn’t win a single game during the preseason and now want to redeem themselves.

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How to Watch

  • When: Sunday, September 7, 1 pm ET
  • Where: Caesars Superdome, New Orleans, Louisiana
  • How to Watch: CBS

Cardinals vs. Saints Odds

TeamMoneylineSpreadTotals
Cardinals-280-6.542.5
Saints+230+6.546.5

Game Preview

The Arizona Cardinals just missed the playoffs last year, but it seems they have the quality to reach the postseason this season. Kyler Murray should have one standout season and prove his worth. After all, he got more than $230 million from the Cards.

Cards defense is significantly better than before. DE Dalvin Tomilson is here, DT Walter Nolen was the 16th pick overall, CB Will Johnson was the second-rounder, etc. So overall, Arizona has a decent team with solid experience.

The Saints, according to many, are one of the worst teams in the NFL. And that’s because they don’t have a QB. Their No. 1 quarterback will be Spencer Rattler, who started seven games last year and lost all of them, completing four touchdown passes and throwing five interceptions.

On the defensive side, things are much better, particularly after Justin Reid came from the Chiefs. DE Cameron Jordan is there, as is LB Chase Young, so they will have some influence in that aspect of the game.

Cardinals vs. Saints Head to Head

There have been 32 games between these two franchises, and the current record is tied, with 16 wins apiece.

Arizona won the previous meeting in 2022, 42-34, in Glendale.

Cardinals vs. Saints Predictions

Arizona looks better, and we believe the guests will have a fairly easy win in this event.

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