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Expert prediction

NFL Week 1: Giants vs. Commanders Preview, Odds, Picks (Sep 7)

  • Nikola Velickovic
  • Aug 31, 2025 at 9:12 AM EDT
  • Giants vs. Commanders odds favor Washington at -260.
  • The total points for this game are set at 44.5.
  • WR Terry McLaurin signed a 3-year $96 million extension with the Commanders.

With the saga regarding Terry McLaurin now finished, the Commanders can fully focus on the season opener against the Giants.

If you are interested in more NFL odds and predictions, follow this link.

How to Watch

  • When: Sunday, September 7, 1 pm ET
  • Where: Northwest Stadium, Washington, DC
  • How to Watch: FOX

Giants vs. Commanders Odds

TeamMoneylineSpreadTotals
Giants+215+6.544.5
Commanders-260-6.544.5

Game Preview

The Giants’ head coach, Brian Daboll, stated that his starting quarterback will be the former NFL Super Bowl champion, Russell Wilson. Now, there’s going to be plenty of pressure on the former Seahawk, who also needs to watch out for Jameis Winston and the rookie Jaxson Dart. Both are waiting on the bench.

Additional pressure comes from the fact that the NYG had all three wins during the preseason, combining for 107 points and allowing 49. This aroused the Giants’ fans, who are now anxious for the regular season to start.

Meanwhile, the Commanders posted all three losses in the preseason. They were terrible on both ends, allowing 109 points and scoring only 38. As stated, with Terry McLaurin’s status finally sorted out, we expect them to be much better.

Also, do you know that the Commanders added DT Javon Kinlaw, CB Jonathan Jones and CB Trey Amos, meaning their defense should be better than last year.

Giants vs. Commanders Head to Head

This longstanding rivalry between the two NFC East teams produced 186 contests. Giants lead 108-73 with 5 ties. Last season, the Commanders won both events, 27-22 in NY and 21-18 at home.

Giants vs. Commanders Predictions

Commanders are favorites, and from our perspective, that’s because of their versatile attack and the home-court edge. These are the only reasons why we bet on their victory in this event.

  • Free NFL picks: Commanders win
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