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Expert prediction

NFL Week 1: Titans vs. Broncos Preview, Odds, Picks (Sep 7)

  • Nikola Velickovic
  • Aug 31, 2025 at 9:40 AM EDT
  • Titans vs. Broncos total is 42.5 points.
  • Tennessee will start with No.1 pick QB Cam Ward.
  • Denver Broncos led the league in sacks last year with 63.

The Denver Broncos want to open the season with a win, and the Titans seem to be a perfect chance for the franchise from Mile High. But the No.1 pick from this draft, Cam Ward, has other intentions.

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How to Watch

  • When: Sunday, September 7, 4:05 pm ET
  • Where: Empower Field at Mile High, Denver, Colorado
  • How to Watch: FOX

Titans vs. Broncos Odds

TeamMoneylineSpreadTotals
Titans+300+8.542.5
Broncos-400-8.542.5

Game Preview

Titans had two wins in the preseason, and they looked good. We haven’t seen much from Ward, who had 10 completions in 19 attempts for 145 yards, yet no touchdowns.

WR Calvin Ridley is questionable, yet we believe he will play this one. The former Falcon had 1,017 yards last year and 4 touchdowns, all that in 64 receptions.

The Broncos had the league-leading 63 sacks last season and are now even stronger on the defensive side with the addition of several experienced players, including LB Greenlaw, S Hufanga, and rookie CB Barron.

QB Bo Nix will be under tremendous pressure. He had 3,775 yards with 29 touchdowns and 12 picks. The Broncos ended the playoff drought with him as the leader, and the expectations are high.

Titans vs. Broncos Head to Head

Titans are better overall, having 25 wins, Broncos 18, and one game ended with a tie.

Titans vs. Broncos Predictions

Playing at the Mile High is a completely different experience for any QB, and we are pretty sure that Ward won’t like it. Particularly due to the Broncos’ ferocious defense. That’s why we bet on Denver to win and cover the spread.

  • Free NFL picks: Broncos -8.5
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