Expert prediction
NFL Week 3: Cardinals vs. 49ers Preview, Odds, Picks (Sep 21)
- Cards vs. 49ers game features two undefeated teams.
- The total for this game is 44.5 points.
- Brock Purdy is out with a toe injury, and Mac Jones will replace him.
The 49ers survived two opening games, but they now have a tough rival coming up to the Bay Area – the Arizona Cardinals, who are also without a loss.
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How to Watch
- When: Sunday, September 21, 4:25 pm ET
- Where: Levi’s Stadium, San Francisco, California
- How to Watch: CBS
Cardinals vs. 49ers Odds
Game Preview
The Cards got the win against the Panthers due to Calais Campbell’s late sack, which put an end to Carolina’s hopes. It was 27-22 for the home team, who beat the Saints in the opening game 20-13 on the road.
Arizona played a bad game, having only 16 1st downs and 293 yards from scrimmage. QB Kyler Murray threw for 220 yards, a pick, and a touchdown, while James Conner ran for a TD but only 34 yards on 11 carries.
The 49ers didn’t have Brock Purdy against the Saints on the road, yet they managed to squeak out a victory, 26-21. Mac Jones was there to step in and amaze everyone with 279 passing yards and 3 touchdown passes. He did lose one fumble, though, but that wasn’t costly in the end.
DL Nick Bosa and the defense helped him a lot because they stopped the Saints when he needed them the most. Bosa had one sack and two QB hits.
Cardinals vs. 49ers Head to Head
Arizona and the Niners met 77 times, with the team from San Francisco leading 36-31. Last season, the Cardinals triumphed in both events, 24-23 on the road and 47-24 at home.
Cardinals vs. 49ers Predictions
Both teams are undefeated, yet their wins weren’t that convincing. The 49ers play tough football, and nobody highlights their defense. Cards haven’t been tested properly, and neither as Jones, so UNDER looks like a safe pick for this event.
- Free NFL picks: Under 44.5 points
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