Premier League: Liverpool vs. Everton Picks, Odds, and Preview (Sep 20)

The first Merseyside derby of the 2025-26 Premier League season is set for this weekend, as Liverpool welcome cross-city rivals Everton to Anfield. Both teams have made excellent starts to the new campaign, but which team will claim the bragging rights? You can find the odds and our picks here.

---

How To Watch

• When: Saturday, September 20, 2025, at 7:30 AM ET
• Where: Anfield, Liverpool, England
• How To Watch: NBC

---

Liverpool vs. Everton Odds

Match Result	Odds
Liverpool	-210
The Draw	+357
Everton	+616

---

Head-to-Head Record

Liverpool hold the upperhand based on recent derby matches with Everton. The Reds have suffered just one home defeat in the last 28 meetings, and they have recorded victories in each of the last four.

---

Match Preview

An early season Merseyside derby is set for Anfield this weekend, and it could be argued that both teams come into this fixture in their best possible form. Liverpool have made a solid start to their Premier League defense, winning each of their opening four.

Despite being unspectacular, the Reds have scored a joint-league high of nine goals. Their tense 1-0 victory against Burnley last Sunday means that the Reds could open an EPL campaign with five straight victories for just the third time in their history.

READ More: USA Today 301 Picks, Odds, and Preview (Sep 21)

Everton’s confidence will be sky high after making an excellent start to the campaign under David Moyes. Their two-game winning sequence was ended last weekend, but plenty of positives could have been taken from their 0-0 draw against Aston Villa.

The Toffees have been impressive on the road under Moyes since the Scotsman returned to the club, as they have won six of their last eleven away matches. All six wins have been recorded in 2025, which is their most in a single calendar year since 2021.

---

Liverpool vs. Everton Picks

Away wins against Liverpool are a rarity for the Toffees, and they have won just two of the last 29 EPL Merseyside derbies. Despite bringing impressive form into this round, it still appears hard to overlook the chances of a home victory at Anfield this weekend.

Free Picks:

• Liverpool (-210)