Expert prediction
NFL Week 4: Saints vs. Bills Preview, Odds, Picks (Sep 28)
- Saints vs. Bills total is 47.5 points.
- The Bills are 15.5-point favorites at the opening.
- Saints to win are +900.
The Bills are the biggest favorites in the NFL Week 4, with a moneyline on them vs. Saints at -1800 and the spread -15.5 points.
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How to Watch
- When: Sunday, September 28, 1 pm ET
- Where: Highmark Stadium, Orchard Park, New York
- How to Watch: CBS
Saints vs. Bills Odds
Game Preview
The Saints posted their third loss in a row, this one much harder than the previous two. They would lose to the Seattle Seahawks at Lumen, 44-13, with their defense being exposed hard.
Additionally, their special team failed to deliver, allowing Seattle to have not only a pick-six punt return but also 206 returning yards in total, which is too much, regardless of the rival and the circumstances.
This is a nice chance for the Bills to rest some of their players who struggle with minor injuries or at least to spare them from getting too many snaps. With all due respect to the Saints, we truly believe that HC Sean McDermott thinks as well.
The Bills’ offense scored 102 points in the opening three games, the second-most in the league behind the Colts, who have one point more. That tells enough about their power.
Saints vs. Bills Head to Head
The result in the all-time series is 7-5 for the Saints, but the last meeting in 2021 ended with the Bills winning 31-6 on the road.
Saints vs. Bills Predictions
The Saints are at least two levels below the Bills, and we don’t mean to offend anyone here. Simply, the difference is too big, and the home team will cover a 15.5-point spread.
- Free NFL picks: Bills -15.5
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