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Expert prediction

NFL Week 4: Panthers vs. Patriots Preview, Odds, Picks (Sep 28)

  • Nikola Velickovic
  • Sep 23, 2025 at 12:18 PM EDT
  • Panthers vs. Patriots total points line is 43.5 points.
  • Carolina Panthers demolished the Falcons last week, 30-0.
  • Patriots allow only 60.3 rushing yards per week, 2nd-fewest in the NFL.

This game could be a turning point in the season for both of these teams. Panthers to secure their second win in a row, and for the Pats to demonstrate mental toughness and resilience.

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How to Watch

  • When: Sunday, September 28, 1 pm ET
  • Where: Gillette Stadium, Foxborough, Massachusetts
  • How to Watch: FOX

Panthers vs. Patriots Odds

TeamMoneylineSpreadTotals
Panthers+195+5.543.5
Patriots-230-5.543.5

Game Preview

Everything was perfect for the Panthers, who trounced the Falcons, 30-0, breaking Michael Penix Jr.’s morale and sending the youngster to the bench. On the other hand, Bryce Young didn’t throw for any touchdowns, having 121 passing yards, though he ran for one.

Chau Smith-Wade had one pick-six for 11 yards, while Rico Dowdle ran for another score on the ground. Overall, the Panthers had 110 yards on the ground.

The Patriots lost to the Steelers because they had 5 turnovers, 4 fumbles, and one interception, with Drake Maye being completely battered throughout the entire event. The Steelers sacked him 5 times, and in the end, it was 21-14 for the guests.

New England’s defense was solid, limiting the Steelers’ rushing to 64 yards. Their average for allowed run yards per game is 60.3, which is the second-fewest in the NFL right now.

Panthers vs. Patriots Head to Head

The overall record is 4-4, with the most recent meeting in 2021, when the Patriots beat Carolina on the road, 24-6.

Panthers vs. Patriots Predictions

The Patriots will expose Young and the Panthers in this one due to their very harsh defense. If Maye has an average performance, this event should end with the Patriots winning by at least a one-touchdown difference.

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