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Expert prediction

NFL Week 4: Titans vs. Texans Preview, Odds, Picks (Sep 28)

  • Nikola Velickovic
  • Sep 23, 2025 at 12:17 PM EDT
  • Titans vs. Texans AFC South matchup is of great importance for both teams.
  • The total for this game is 39.5 points.
  • Both teams are 0-3.

Things are very tough for both the Titans and the Texans, as a loss here would likely eliminate them from the playoff race.

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How to Watch

  • When: Sunday, September 28, 1 pm ET
  • Where: NRG Stadium, Houston, Texas
  • How to Watch: CBS

Titans vs. Texans Odds

TeamMoneylineSpreadTotals
Titans+280+6.539.5
Texans-360-6.539.5

Game Preview

Titans allowed 94 points in the opening three weeks, and their defense is the 2nd-worst in this category in the entire league. The only team with more points allowed is Miami with 97.

No.1 pick from this draft, QB Cam Ward had 219 passing yards for one TD and one pick. He was sacked four times, and had 23 completions in 38 passing attempts. Also, the Titans haven’t recorded a single sack in this game.

Texans are in trouble, and the chemistry is falling apart in the locker room, according to various speculations and footage on the net. The rivals easily read QB CJ Stroud, and we saw that in Jacksonville when Houston lost 17-10.

Stroud had 204 passing yards for one touchdown but two picks. WR Nico Collins had a good game with 104 receiving yards and a touchdown, but he fumbled the ball in the crucial moment, allowing the Jags to eventually win.

Titans vs. Texans Head to Head

After 46 games, the result is 24-22 for the Titans. Last year, each team got a win on the road, Houston in Nashville, 23-14, and the Titans in Texas, 32-27.

Titans vs. Texans Predictions

If the Texans lose here, DeMeco Ryans will probably fly. Overall, the hosts have a better team, with better players, and they play at home. Because of that, we will bet on the Texans to triumph.

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