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Expert prediction

NFL Week 4: Browns vs. Lions Preview, Odds, Picks (Sep 28)

  • Nikola Velickovic
  • Sep 24, 2025 at 5:05 AM EDT
  • Browns vs. Lions odds favor Detroit to win at -550.
  • The Detroit Lions have the 2nd-best attack in the NFL, 34.3 ppg.
  • Browns allow the fewest yards per game in the league, 204.3.

After beating the Packers, the Cleveland Browns are now heading to Detroit to meet the fired-up Lions. This will be the battle between rock-solid defense and rocket attack.

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How to Watch

  • When: Sunday, September 28, 1 pm ET
  • Where: Ford Field, Detroit, Michigan
  • How to Watch: FOX

Browns vs. Lions Odds

TeamMoneylineSpreadTotals
Browns+380+8.544.5
Lions-550-8.544.5

Game Preview

The Browns flipped the result against the Packers, coming back from behind and stunning Green Bay in the last quarter. It was 13-10, with Andre Szmyt’s 55-yard field goal as the time expired.

Cleveland allows the fewest yards from scrimmage per game, with 204.3 yards, and the same holds for rushing yards, at 57.3 yards. Veteran QB Joe Flacco is underachieving, posting only 2 touchdown passes and 4 interceptions.

Meanwhile, Jared Goff leads the Lions perfectly, as he racked up 761 passing yards, 7 TD passes and only one pick. Lions are the second-best scoring offense in the league, with 34.3 points per game.

They defeated the Ravens on Monday Night Football, 38-30, on the road, not due to the offense but to the defense. Lions sacked Lamar 7 times, with Al-Quadin Muhammad posting 2.5 sacks. Also, RB David Montgomery had 151 rushing yards for 2 TDs.

Browns vs. Lions Head to Head

Lions lead 19-6 overall, and the last game was in 2021, when Cleveland won at home, 13-10.

Browns vs. Lions Predictions

The Cleveland Browns have been more than strong on the defensive side, but with Flacco on board, their offense is, let’s say, below average. No matter the Browns’ defense, they won’t restrain the Lions, and our pick here would be Detroit to cover the spread.

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