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Expert prediction

NFL Week 5: Titans vs. Cardinals Preview, Odds, Picks (Oct 5)

  • Nikola Velickovic
  • Sep 30, 2025 at 7:21 PM EDT

Pick rationale

Analysis & key factors

  • Titans vs. Cardinals odds favor Arizona at -450.
  • Kyler Murray has 742 passing and 148 rushing yards this year.
  • Arizona is 1-3 on Over/Under this season.

Cam Ward sure as hell didn’t expect to start his NFL stint with 4 losses in a row. On the other hand, the Cardinals play tough games without many points being involved.

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How to Watch

  • When: Sunday, October 5, 8:05 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: CBS

Titans vs. Panthers Odds

TeamMoneylineSpreadTotals
Titans+340+7.541.5
Cardinals-450-7.541.5

Game Preview

Cam Ward suffered 17 sacks in the opening 4 matches of his NFL career. His Titans are 0-4, and the tension is slowly starting to build up, with the fans becoming nervous due to the poor start of their favorites.

Tennessee is the worst team in the NFL in yards from scrimmage, passing yards, and points per game. Now, this pretty much suggests that the team from Nashville is the worst in the league currently.

Arizona still adapts to James Conner’s absence, and for the time being, that process isn’t going well. Over the last two events, the Cards posted a pair of losses, though tight ones, we have to admit.

After losing in San Francisco, 16-15, they were defeated at home to another NFC West rival, the Seattle Seahawks, 23-20. Murray had two touchdowns but also threw two interceptions and was sacked six times.

Titans vs. Cardinals Head to Head

Tennessee and Arizona have met 12 times, and the current record stands at 8-4 in favor of the Cards.

Titans vs. Cardinals Predictions

This is an excellent opportunity for the Cardinals to win and enter the positive zone, while also recovering from Conners’ injury and getting back on the winning path. Tennessee simply isn’t good enough to challenge them, as they currently stand for the weakest team in the NFL.

  • Free NFL picks: Cardinals -7.5
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