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Expert prediction

NFL Week 5: Lions vs. Bengals Preview, Odds, Picks (Oct 5)

  • Nikola Velickovic
  • Oct 1, 2025 at 5:23 AM EDT
  • Lions vs. Bengals game odds heavily favor Detroit at -650.
  • Detroit Lions score the most points in the NFL per game, 34.2.
  • The Bengals are beheaded without Joe Burrow.

On paper, this should be an easy one for the Lions, yet the Bengals won’t go down without a fight. Let’s see if Jake Browning managed to improve a bit.

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How to Watch

  • When: Sunday, October 5, 4:25 pm ET
  • Where: Paycor Stadium, Cincinnati, Ohio
  • How to Watch: FOX

Lions vs. Bengals Odds

TeamMoneylineSpreadTotals
Lions-650-10.549.5
Bengals+425+10.549.5

Game Preview

Jared Goff and the boys score 34.2 points per game, the most in the NFL, yet the veteran has been sacked 14 times this year, which is the second-highest total among all quarterbacks.

Goff already threw for 929 yards and has 9 TD passes and two picks. His top target is Amon-Ra St. Brown, who has 6 receiving touchdowns and is on the path to having a great season. One more guy is shining, only on the defensive side, DE Aidan Hutchinson, with 4 sacks so far.

Jake Browning experienced pain in Denver, where the Broncos trashed the Bengals, 28-3. He was hit 6 times and suffered three sacks, ending the night with just 125 passing yards.

The Bengals’ rushing was terrible, as they managed to generate just 53 yards on the ground on 15 carries. And without the starting QB, this is a one-way ticket to defeat. Do notice that the Bengals didn’t have a single turnover yet, yet they still lost this big.

Lions vs. Bengals Head to Head

The Bengals have 7 wins in a row over the Lions, and they lead the all-time series 10-3.

Lions vs. Bengals Predictions

This game will be excellent for some stat-padding by the Lions, whose offense is going to roll over the Bengals and score like 35+ points. The home team is falling apart, and their loss is inevitable here.

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