Expert prediction
NFL Week 6: 49ers vs. Buccaneers Preview, Odds, Picks (Oct 12)
- Nikola Velickovic
- Oct 7, 2025 at 10:41 AM EDT
- 49ers vs. Buccaneers moneyline favors the Bucs at -155.
- Both teams are 4-1 at the moment.
- The 49ers average 290.6 passing yards per game, No.1 in the NFL.
Both teams are banged up and injured, with them having several starters out and several more struggling with fitness. So this one will be more about the will to win.
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How to Watch
- When: Sunday, October 12, 4:25 pm ET
- Where: Raymond James Stadium, Tampa Bay, Florida
- How to Watch: CBS
49ers vs. Buccaneers Odds
Game Preview
San Francisco 49ers beat the Rams on Thursday Night Football after a fierce battle and overtime, 26-23. Again, Mac Jones led the way, with him slowly putting pressure on Kyle Shanahan’s decision to name Brock Purdy the starting QB.
Jones had 342 passing yards for two touchdown passes and was unstoppable in some moments. In only three games this year, Jones generated 905 passing yards for 6 TDs and was picked just once. Far better than Purdy.
HAVE. A. DAY. pic.twitter.com/4Fk8ylrv8x
— Tampa Bay Buccaneers (@Buccaneers) October 6, 2025
Tampa Bay looks good. That loss to the Eagles shouldn’t have happened, with the official slightly pushing the Super Bowl champs. Though, Baker Mayfield and the boys bounced back with a 38-25 win over the Seahawks on the road. Bucs are the first team with 4 wins in the opening 5 rounds all of which are with three points or fewer.
Baker had 379 passing yards against the Seahawks, with two touchdown passes. His passer rating was 134.7, and in the key moments, the former No.1 pick dominated. Meanwhile, Bucky Irving’s absence wasn’t covered up in terms of productivity, but Rachaad White delivered 2 touchdowns on the ground.
49ers vs. Buccaneers Head to Head
The 49ers have a 21-7 lead in the all-time series. They have four straight wins, with their last triumph coming in November 2024, 23-20 on the road.
49ers vs. Buccaneers Predictions
This game is going to deliver a high number of points because both teams have very talented offenses but mediocre defensive teams. Additionally, they are focused on passing right now, meaning they will move the chains quickly. Our pick for the 49ers vs. Bucs game is Over 47.5 points.
- Free NFL Picks: Over 47.5 points
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