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Expert prediction

NFL Week 6: Lions vs. Chiefs Preview, Odds, Picks (Oct 12)

  • Nikola Velickovic
  • Oct 7, 2025 at 5:11 PM EDT
  • Lions vs. Chiefs total is set at 51.5 points.
  • Patrick Mahomes is the Chiefs’ best rusher with 190 yards.
  • Detroit Lions are the No.1 offense in the league, 34.8 points per game.

The Detroit Lions are the best offense in the league, but they now head to Arrowhead Stadium to meet the three-time Super Bowl champions, the Kansas City Chiefs.

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How to Watch

  • When: Sunday, October 12, 8:20 pm ET
  • Where: GEHA Field, Kansas City, Missouri
  • How to Watch: NBC

Lions vs. Chiefs Odds

TeamMoneylineSpreadTotals
Lions+115+2.548.5
Chiefs-135-2.548.5

Game Preview

Jared Goff leads the best offense in the league, as the Lions score 34.8 points per game. They are looking very good on the offensive side of the ball, with a balanced and smooth approach. Apart from the opening week against the Packers, in all the following games, Detroit scored at least 34 points.

Beating the Bengals on the road, 37-24, isn’t anything special because Cincinnati seems helpless without Burrow. Goff had 258 passing yards with three touchdown passes, while David Montgomery threw one too, apart from rushing one.

The Chiefs looked as if they had everything under control in Jacksonville, but a slow finish cost them a win in Florida. It was 31-28 for the Jags, who won in the last minute of the event. The key moment of the match was when Devin Lloyd picked off Mahomes’ pass and returned it for 99 yards.

An alarming statistic for Kansas City is that Mahomes has the most rushing yards this year. They had 158 vs. the Jags, but Mahomes generated 60 with one touchdown, risking some hard hits and a potential injury.

Lions vs. Chiefs Head to Head

There have been 15 games between these teams, and the series result is 9-6 in favor of the Chiefs. The most recent was in 2023 when the Lions won 21-20 in Kansas City.

Lions vs. Chiefs Predictions

We are going to take Over 51.5 points, because there’s absolutely no reason not to see one hell of an offensive performance on both sides. Neither defense is really reliable, but the offenses are.

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