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Expert prediction

NFL Week 7: Packers vs. Cardinals Preview, Odds, Picks (Oct 19)

  • Nikola Velickovic
  • Oct 14, 2025 at 5:53 PM EDT
  • Packers vs. Cardinals odds favor Green Bay.
  • The Arizona Cardinals have 4 straight losses.
  • Green Bay has the best run defense in the league, 73 yards per game.

The Packers won last weekend, while the injury-banged Cards narrowly lost to the Colts in Indianapolis. This should be an interesting game for the NFL betting fans, so stay tuned and see some tips.

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How to Watch

  • When: Sunday, October 19, 4:25 pm ET
  • Where: State Farm Stadium, Glendale, Arizona
  • How to Watch: FOX

Packers vs. Cardinals Odds

TeamMoneylineSpreadTotals
Packers-300-6.544.5
Cardinals+250+6.544.5

Game Preview

The Packers haven’t been that confident at Lambeau against the Bengals, led by Joe Flacco, the only QB to beat Green Bay this season (while playing for the Browns). Packs won 27-18, but it wasn’t easy at all.

RB Josh Jacobs had 93 rushing yards and two touchdowns on the ground, along with 57 receiving yards, making him the absolute best player on the home team. Jordan Love threw for 259 passing yards, and he had one touchdown and one interception.

The Cardinals played well without several of their starters, among them Kyler Murray. Jacoby Brissett was solid while replacing him with 320 passing yards for two scores and one interception.

Calais Campbell had 3 QB hits, and the defense wrestled with the Colts, but in the end, the Cards fell 31-27. Running was the biggest problem for Arizona, which eventually had only 88 rushing yards in 24 carries, or only 3.7 per carry.

Packers vs. Cardinals Head to Head

The Packs lead the series 47-26-4, and they’ve defeated the Cards last season, 34-13 at home.

Packers vs. Cardinals Predictions

We still don’t know who will play for the Cardinals because of all the injuries and recoveries. The Packers oscillate, and we don’t believe in Love that much to bet on them. Arizona’s home defense is respectable, holding rivals to about 20 points, so we are going with under here because Green Bay has a decent defense, too.

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