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Expert prediction

NFL Week 8: Titans vs. Colts Preview, Odds, Picks (Oct 26)

  • Nikola Velickovic
  • Oct 22, 2025 at 4:47 AM EDT
  • Titans vs. Colts is an AFC South divisional rivalry.
  • Tennessee Titans head coach Mike McCoy needs to find a way to stabilize the team.
  • The Colts are 14.5-point favorites in this event.

The NFL Odds say everything here; the Colts are absolute favorites and are expected to post an easy win. Though the Titans have no pressure, they come to Lucas Oil searching for a sensation.

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How to Watch

  • When: Sunday, October 26, 4:25 pm ET
  • Where: Lucas Oil Stadium, Indianapolis, Indiana
  • How to Watch: CBS

Titans vs. Colts Odds

TeamMoneylineSpreadTotals
Titans+800+14.547.5
Colts-1600-14.547.5

Game Preview

The Tennessee Titans have a new head coach and the No.1 pick, who must be adequately developed. Right now, the situation isn’t great, but HC McCoy needs to find some sort of balance and protect Cam Ward.

A win over Arizona in Glendale made the fans hope for more, but two losses afterward —one 20-10 in Las Vegas and another at home vs. the Patriots, 31-13 —quickly brought them back to reality.

Indianapolis Colts lead the way in the AFC. Daniel Jones is leading the most efficient team in the league with 33.1 points per game and is playing the football of his life. Though, that’s much easier when you have the best running back in the NFL – Jonathan Taylor.

Taylor has run 131 times so far and posted 697 yards on the ground with 10 touchdowns. His trajectory might be historic if he keeps this pace. We have to say that Taylor has 185 receiving yards too, for one touchdown.

Titans vs. Colts Head to Head

Indianapolis has 5 straight wins over the Titans, and they lead the all-time series, 40-22. They already met once this year, and the Colts beat the Titans on the road, 41-20.

Titans vs. Colts Predictions

The Colts’ high-octane offense is too much for some Super Bowl contenders, let alone a struggling team, one of the weakest in the league. That said, our final pick is Colts -14.5.

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