Expert prediction
NFL Week 16: Atlanta Falcons vs. Arizona Cardinals Preview, Odds, Picks (Dec 21)
- Nikola Velickovic
- Dec 17, 2025 at 4:14 PM EST
- Falcons vs. Cardinals odds favor Atlanta by 2.5 points.
- TOTAL went OVER in 6 of Atlanta’s last 7 games.
- Arizona Cardinals have lost their previous 6 matches.
Atlanta oscillates, though it shows its fighting spirit ahead of the game in Arizona, whereas the Cardinals wait until the season ends.
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How to Watch
- When: Sunday, December 21, 4:05 pm ET
- Where: State Farm Stadium, Glendale, Arizona
- How to Watch: FOX
Falcons vs. Cardinals Odds
Game Preview
This will be the Cards’ 4th road game in the last 5. Overall, they’ve played well during this stretch, winning two, losing two by narrow margins, and being blown out by the NFC leaders, the Seahawks. Overall, this team is on the decline in the second part of the campaign.
Zane Gonzales’ walk-off field goal from 42 yards brought them the win over divisional rivals, the Buccaneers, on the road. It was 29-28 for the Falcons, who beat the Saints three weeks before, also on the road, 24-10.
Carson Palmer is the ONLY QB to have a winning record on the Arizona Cardinals (min 10 starts)
— Zay (@TheMarvSpace) December 15, 2025
Yes, that stat is as sad as it sounds. pic.twitter.com/K0pkl023Ki
Arizona benched Kyler Murray and is now trying to find some groove with Jacoby Brissett. Though, some believe they are tanking to get the best possible position at the upcoming draft.
The defense is terrible, allowing 40 or more points in three of the past 5 contests. We do have to say that the Cards have plenty of absent players, some injured, some simply spared of any risk this season, so overall, their results aren’t that odd.
Falcons vs. Cardinals Head to Head
After 34 matches, the Cardinals have 18 wins and the Falcons 16. The last one was in 2023 when Arizona won 25-23 at home.
Falcons vs. Cardinals Predictions
Atlanta plays better than Arizona, and that’s obvious in these past few events. We back up the unit from Georgia to win because of better form and performances lately.
Free NFL Picks: Falcons Win
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