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Expert prediction

NFL Week 17: New Orleans Saints vs. Tennessee Titans Preview, Odds, Picks (Dec 28)

  • Nikola Velickovic
  • Dec 23, 2025 at 3:40 AM EST

Pick rationale

Analysis & key factors

  • Saints vs. Titans odds slightly favor New Orleans at -150.
  • New Orleans Saints have three wins in a row.
  • The Titans beat the Chiefs 26-9 last weekend.

The New Orleans Saints have been superb over the last three games, and we can say the Titans have also shown a sharp improvement in form. The two rivals now meet in Week 17.

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How to Watch

  • When: Sunday, December 28, 1 pm ET
  • Where: Nissan Stadium, Nashville, Tennessee
  • How to Watch: CBS

Saints vs. Titans Odds

TeamMoneylineSpreadTotals
Saints-150-2.539.5
Titans+125+2.539.5

Game Preview

The New Orleans Saints have their new QB. Tyler Shough should be their new leader, because this guy plays excellent football. The three wins in a row the Saints posted are because of his leadership, and that’s a fact.

In wins over the Buccaneers, Panthers, and the Jets, he had 724 passing yards, two touchdown passes, one interception, and two rushing touchdowns. So, he’s the guy.

Titans won two of the last three. After beating the Browns on the road, 31-29, then losing to the 49ers in Cisco, 37-24, this unit was better than the Chiefs, 26-9, last Sunday in Nashville. This was their first win after 11 straight at home.

Cam Ward had 228 passing yards for two touchdown passes. Meanwhile, Tony Pollard had a good game, posting 102 rushing yards on 21 carries, and overall, the Titans racked up 164 yards on the ground.

Saints vs. Titans Head to Head

After 17 games in the all-time series, the result is 9-7-1 in Tennessee’s favor.

Saints vs. Titans Predictions

New Orleans Saints have been on fire, and even though the Titans play much better football than before, our pick in this one is the guests. They have a much better team overall and better defense than the Titans.

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