Expert prediction
NFL Week 18: Seattle Seahawks vs. San Francisco 49ers Preview, Odds, Picks (Jan 3)
- Nikola Velickovic
- Dec 29, 2025 at 4:50 PM EST
Pick rationale
Analysis & key factors
- Seahawks vs. 49ers odds favor Seattle at -120.
- The TOTAL for this game is 49.5 points.
- This game decides the top spot in the NFC conference.
Whoever wins here can lock the top seed in the NFC. Injured 49ers are battling with the current NFC West and the conference leaders, the Seahawks, whom they already defeated once this year.
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How to Watch
- When: Saturday, January 3, 8 pm ET
- Where: Levi’s Stadium, San Francisco, California
- How to Watch: ABC
Seahawks vs. 49ers Odds
Game Preview
Seattle is 13-3, and the Seahawks rolled over the Panthers in Charlotte last weekend, 27-10. After back-to-back tight wins, they finally had one game where the rivals didn’t stand a chance, controlling everything right from the start until the end.
San Darnold threw one interception and was pretty bad overall, with 147 passing yards and one more TD pass. He lost a fumble as well. RB Zach Charbonnet ran 110 yards for two scores and was unstoppable.
The @49ers will debut their “For the Faithful” NFL x Nike Rivalries uniforms in Week 18 against the Seahawks 🔥
— NFL (@NFL) December 29, 2025
SEAvsSF– Saturday 8pm ET on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/YaTDFHl5or
The San Francisco 49ers are in an even better shape, and what amazes all gridiron fans is the fact that Kyle Shanahan plays without most of his best players for a long time.
The Niners’ offense is fantastic, scoring 127 points in the past three events. Sunday Night Football against the Bears ended 42-38 for San Francisco. Purdy threw three TD passes and one pick, and 303 passing yards, and he also had two rushing scores, while Christian McCaffrey had 140 rushing yards for a TD.
Seahawks vs. 49ers Head to Head
The first game of the year in Seattle saw the Niners winning, 17-13.
Seahawks vs. 49ers Predictions
We have to pick the Niners here, because we truly believe that Darnold can’t keep up with the offensive pace guests impose. He is still not good enough to win these games, and at some point in the season, the defense won’t be able to cover for his mistakes. That moment is now.
- Free NFL Picks: 49ers
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