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Expert prediction

AFC Divisional Round: Bufallo Bills vs. Denver Broncos Preview, Odds, Picks (Jan 17)

  • Nikola Velickovic
  • Jan 13, 2026 at 11:18 AM EST

Pick rationale

Analysis & key factors

  • Bills vs. Broncos odds favor Denver by 1.5 points.
  • The total for the Bills vs. Broncos game is 46.5 points.
  • Buffalo blew away Denver last year in the AFC Wild Card game, 31-7.

The game at the Mile High should be epic, with both teams going for a win. And both are Super Bowl contenders.

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How to Watch

  • When: Saturday, January 17, 4:30 pm ET
  • Where: Mile High, Denver, Colorado
  • How to Watch: CBS

Bills vs. Broncos Odds

TeamMoneylineSpreadTotals
Bills-105+1.546.5
Broncos-115-1.546.5

Bills vs. Broncos Preview

The Bills will be pretty banged up in this game, with several players out due to injuries or not 100% fit. Kicker Matt Prater has problems with his quad, WR Gabe Davis is out, and S Jordan Poyer is out too.

Against the physical Broncos, this will be a big blow for Sean McDermott’s unit, and all eyes will be pointed towards Josh Allen, who really needs to be in his Superman mode here. In a 27-24 win over the Jags, he had 273 passing yards for one TD pass and two rushing scores. and 33 yards on the ground.

The Broncos had one week to rest and fully recover, and come into this event regenerated and ready for the Bills. After a period of pretty shaky performances (defensively, not overall), Denver showed its true face when beating the mixed Chargers in the final round, 19-3.

Before that, we saw them struggling to get things going on defense, allowing too many points against the Raiders, Packers, and Jags. Luckily, in most cases, their attack was up to the task.

Bills vs. Broncos Head to Head

The last meeting between the two sides was in the AFC Wild Card round in 2025, and the Bills triumphed at home, 31-7.

Bills vs. Broncos Predictions

The Buffalo Bills have problems with injuries, and that’s the only reason why we pick the Broncos to win this one. Nothing else. In terms of play, these teams are pretty leveled, but rest and health point to Denver.

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