Columbus Crew vs. St. Louis SC U.S. Open Cup Final Picks, Odds, and Betting Analysis for Oct 21, 2026

• Columbus Crew host St. Louis SC at ScottsMiracle-Gro Field in the 2026 U.S. Open Cup Final.
• Crew are aiming to win the domestic honor for the first time since 2002.
• St. Louis SC have never previously won a domestic trophy.

Major silverware will be on the line in North America on Oct 21, as the 2026 U.S. Open Cup Final is staged at ScottsMiracle-Gro Field. The Columbus Crew will be aiming to win the honor for the second time, while St. Louis SC will be hoping to secure a historic first major honor. You can find the latest odds available at the best soccer betting sites and our Columbus Crew vs. St. Louis picks here.

Columbus Crew vs. St. Louis SC Betting Odds

Match Result	Odds
Columbus Crew	TBC
The Draw	TBC
St. Louis SC	TBC

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How to Watch

• When: Wednesday, October 21, 2026. 8:00 PM ET
• Where: ScottsMiracle-Gro Field, Columbus, Ohio
• How to Watch: CBS, Paramount+

ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis

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U.S. Open Cup Final Betting Preview

Crew Set Sights on Second Honor

Laurent Courtois has only been in charge of the Columbus Crew since May, but the interim boss could lead the team to a historic feat in the U.S. Open Cup Final. The Crew have only won the major honor once, with their maiden success coming back in 2002.

Columbus have battled through four rounds to reach the final, beating FC Tulsa and Chicago Fire in the opening two rounds, before requiring a penalty shootout to see off the Houston Dynamo in the quarterfinals. Their spot in the final was assured after beating the Colorado Rapids away from home in the semi-finals last month.

Likely Lineup:

(3-4-3) Schulte (GK); Moreira, Zawadzki, Amundsen; Farsi, Chambost, Harbroune, Zaroury; Mendez, Martinez, Rodriguez

St. Louis Chasing a Historic First

St. Louis SC will have the weight of history on their shoulders this week, as they bid to win a first-ever major trophy in the 2026 U.S. Open Cup Final. Yoann Darnet’s team overcame lower-ranked Richmond Kickers and One Knoxville in the opening two rounds, before seeing off MLS rivals New York City FC and Orlando City in the quarterfinals and semi-finals, respectively.

They look more than ready for this challenge, and they certainly bring the best form into the final after going 19 matches without defeat. Notably, they have also won four of their previous five.

Likely Lineup:

(3-4-3) Burki (GK); Polvara, Baumgartl, Fall; Wallem, Durkin, Edelman, Totland; Holse, Navarro, Matan

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Head-to-Head Betting Stats

• Columbus Crew boast a 100% record against St. Louis, winning both previous encounters.
• The Crew won the latest encounter 2-1 in April 2025.
• Both teams have scored in both head-to-head encounters.

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U.S. Open Cup Final Betting Picks

Despite never beating the Columbus Crew, St. Louis SC come into the U.S. Open Cup Final as the logical play. They have avoided defeat in their last 19 in the MLS, winning an impressive 13 games over that period. In contrast, the Crew have largely been inconsistent since returning to action after the World Cup, losing seven of their last eleven in the MLS.

• St. Louis SC

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How to Bet On The U.S. Open Cup

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