MLB: 4 Upset Predictions for Today

The regular season in the MLB is reaching its closing stages, and the pressure will continue to intensify with some teams still yet to confirm their spots in the postseason.

The pressure will be off the likes of the Tampa Bay Rays, New York Yankees, and Atlanta Braves with their spots in the playoffs confirmed. But, as it typically the case, upsets could be likely in the final weeks of the regular season. You can find our four MLB upset predictions for today here.

MLB Best Bets & Top Value Picks

• Best Pick: Philadelphia Phillies (vs. Milwaukee Brewers)
• Best Value: Seattle Mariners (vs. Houston Astros)
• Team to Fade: Washington Nationals (vs. Detroit Tigers)

ALSO SEE: Presidents Cup Picks, Odds & Betting Preview (Sep 24-27)

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MLB Upset Predictions Today: Key Game Breakdown & Predictions

New York Yankees vs. Tampa Bay Rays Prediction & Odds

Date: Tuesday, September 22 | Yankee Stadium, New York 

Game Preview

The New York Yankees have already secured their spot in the postseason, meaning that it is likely that they will take their foot off the gas in the final weeks of the regular season. Tampa have been regular forces on the road this season, especially when the odds have been against them. The depth of the Rays’ bullpen could give them a healthy advantage, especially after winning eight of their last nine games.

• Best Bet: Tampa Bay Rays (+109) 

Boston Red Sox vs. Cleveland Guardians Prediction & Odds

Date: Tuesday, September 22 | Fenway Park, Boston

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The Boston Red Sox have been vulnerable at Fenway Park throughout the season, going 38-37 in 2026. Therefore, the Cleveland Guardians provide a value selection when assessing the MLB upset predictions for today. The Guardians have shown a clinical nature on the road, going 40-35. Meanwhile, the Guardians have been in red-hot recent form, winning each of their previous five games.

• Best Bet: Cleveland Guardians (+109)

Texas Rangers vs. New York Mets Prediction & Odds

Date: Tuesday, September 22 | Globe Life Field, Arlington 

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The Texas Rangers have been solid throughout the season, but this period of the campaign could be the opportunity to oppose Skip Schumaker’s team. They have suffered defeats in two of their last four, while the New York Mets have won two of their previous three against the Phillies. Sean Manaea could be an important player for the visitors this week, as his deceptive arm angle could ensure a tough matchup for the power-heavy Rangers’ lineup.

• Best Bet: New York Mets (+127)

Atlanta Braves vs. Cincinnati Reds Prediction & Odds

Date: Tuesday, September 22 | Truist Park, Atlanta 

Game Preview

The Atlanta Braves have been one of the dominant forces in the NL East this season, but they could be vulnerable against the visiting Cincinnati Reds this week. Andrew Abbott’s high-spin fastball could give the visitors a good chance of limiting the early-slugging ability of the Braves. The Reds will also take confidence from their 6-4 win over the Braves from earlier in the summer.

• Best Bet: Cincinnati Reds (+163)