Expert prediction
NFL Week 1: Broncos vs. Chiefs Preview, Odds, Predictions (Sep 14)
Pick rationale
Analysis & key factors
- Broncos vs. Chiefs odds favor Kansas City at -130.
- Patrick Mahomes is back following his season-ending ACL injury.
- Bo Nix and the Broncos won the AFC West last year.
Mahomes is back, and the Chiefs want their throne back. The best way to take the first step toward that goal is to beat last year’s AFC West champs, the Denver Broncos.
Check for more NFL odds and picks here.
Game Preview
- When: Monday, September 14, 2026, 8:15 PM ET
- Where: Arrowhead Stadium, Kansas City, Missouri
- How to Watch: ESPN, ABC
Broncos vs. Chiefs Odds
Game Preview
With Patrick Mahomes healthy, the Chiefs are among the Super Bowl contenders once again. According to NFL Comeback Player of the Year odds, Mahomes is the top favorite to win this award, and if his Chiefs win the division, we are sure that the former MVP will add one more trophy to his collection.
Kansas City boosted its backfield with RB Kenneth Walker III, who landed following a Super Bowl win. The defense is rejuvenated with two draft picks, CB Mansoor Delane and DT Peter Woods. There are several more additions to that part of the team, and we can’t wait to see how they fit in.
Sean Payton and Bo Nix are now the guys to beat. And do know that the entire league will be after the Broncos following last year’s AFC Championship Game. Nix got a fantastic target after the Broncos traded for WR Jaylen Waddle, who will be a huge addition to the offense.
Regarding the defense, Denver had one of the best, if not the best, in the NFL last year. Broncos recorded 68 sacks, the most in the league, and were fantastic when it came to pass rush. After all, that’s the main reason why this team reached so deep in the playoffs.
Broncos vs. Chiefs Head to Head
This rivalry has seen 132 games. Chiefs lead the all-time series, 73-59. However, the Broncos won the last three games.
Broncos vs. Chiefs Predictions
It appears that the Chiefs had a busier offseason, so they might need a bit more time to click. Plus, Mahomes is a bit rusty and unsure of himself, so we have to side with the Broncos here, who are the underdogs. We will pick them to defend the spread.
- Free NFL Pick: Broncos +3
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