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Expert prediction

NFC Divisional Round: San Francisco 49ers vs. Seattle Seahawks Preview, Odds, Picks (Jan 17)

  • Nikola Velickovic
  • Jan 13, 2026 at 11:18 AM EST

Pick rationale

Analysis & key factors

  • 49ers vs. Seahawks moneyline favors Seattle at -380.
  • George Kittle is out for the 49ers.
  • Seattle won the NFC No. 1 seed.

The 49ers really don’t have luck with injuries, and their latest star sidelined is George Kittle.

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How to Watch

  • When: Saturday, January 17, 8 pm ET
  • Where: Lumen Field, Seattle, Washington
  • How to Watch: FOX

49ers vs. Seahawks Odds

TeamMoneylineSpreadTotals
49ers+280+7.545.5
Seahawks-355-7.545.5

49ers vs. Seahawks Preview

The Niners beat the Eagles, 23-19, but lost George Kittle, arguably the best tight end in the league. Many are already suggesting that this unit has nothing to hope for against the Seahawks next weekend.

However, the 49ers beat the team with the best defense in the league since the trade deadline, using their own weapon. Defensive coordinator Robert Saleh stiffed Hurts, Barkley and the boys, and hopes to do the same with Darnold.

As for the Seahawks, they have one of the most balanced teams in the NFL. An interesting thing is that their previous event was against the 49ers, 13-3, in San Francisco, where they secured a top seed in the conference in a direct matchup.

Seattle has the league’s top defense, allowing 17.2 points per game, and the third-best offense, scoring 28.4 points per game. That explains a lot why Darnold and the guys had 14 wins.

49ers vs. Seahawks Head to Head

These NFC West divisional rivals have met twice this year, and each side has a win on the road, 17-13 for the Niners in Seattle and 13-3 for the Seahawks in the Bay Area.

49ers vs. Seahawks Predictions

Injuries will play a key role here, and in this case, the Seahawks have a massive edge over the Niners, who simply can’t get over Seattle’s defense without Kittle.

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