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Expert prediction

NFC Wild Card: San Francisco 49ers vs. Philadelphia Eagles Preview, Odds, Picks (Jan 11)

  • Nikola Velickovic
  • Jan 5, 2026 at 4:01 AM EST

Pick rationale

Analysis & key factors

  • 49ers vs. Eagles odds put Philadelphia as the favorite at -220.
  • The Niners lost to the Seahawks last weekend, 13-3 at home.
  • Eagles have the 5th-best defense in the NFL, 19.1 points per game allowed.

For many, this is the best game of the Wild Card round. The Super Bowl champions await one of the best teams in the NFL.

If you want more NFL odds and predictions, please follow this link.

How to Watch

  • When: Sunday, January 11, 4:30 pm ET
  • Where: Lincoln Financial Field, Philadelphia, Pennsylvania
  • How to Watch: FOX

49ers vs. Eagles Odds

TeamMoneylineSpreadTotals
49ers+180+3.546.5
Eagles-220-3.546.5

Game Preview

San Francisco had a chance to win the NFC, but a pretty unexpected and very painful home loss to Seattle pushed them down to seed No. 6. Shanahan’s brilliant offense just collapsed, scoring only 3 points. Brock Purdy had 127 passing yards with one interception.

Meanwhile, the rushers gained only 53 yards on the ground, with Christian McCaffrey having 23. What decided the game was Seattle’s run game, which had 180 yards.

The Eagles lost to the Commanders, losing second place in the NFC. Though he rested Hurts, Barkley, and several other starters, and to be honest, that was more important than the position in the standings.

Philly has the 5th-best defense in the NFL, but according to advanced metrics, it has dominated this aspect of play since the trade deadline and leads the way in many statistical categories.

49ers vs. Eagles Head to Head

The result in the all-time series is 21-15-1 in favor of the Niners. Philly won in the 2023 NFC Championship game, 31-7 at home, but 10 months later, the Niners got even, 42-19 also in Philly.

49ers vs. Eagles Predictions

The Eagles are playing rough football these days, and there’s nothing beautiful in it. Though they are winning, and it seems the additions during the trade deadline were fantastic. San Francisco battles numerous injuries (even Purdy has some minor issues), and no matter Shanahan’s offensive mind, they have slim chances of beating the champs on the road.

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