Expert prediction
NFL Preseason Week 3: Chargers vs. 49ers Preview, Odds, Picks (Aug 23)
- Chargers vs. 49ers total is 35.5 points.
- Trey Lance did well in the preseason.
- Mac Jones is questionable, and we should see Brock Purdy in action.
The Chargers lost to the Rams last weekend by a point, while the 49ers beat the Raiders on the road by three. These two teams have grown accustomed to playing close matches and let’s hope this one will be like that too.
If you are interested in more NFL odds and predictions, follow this link.
How to Watch
- When: Saturday, August 23, 8:30 pm ET
- Where: Levi’s Stadium, San Francisco, California
- How to Watch: ESPN Unlimited, CBS San Francisco
Chargers vs. 49ers Odds
Game Preview
The LA Chargers had the best defense in the NFL during the 2024 season. That trend of rock-solid defense has continued throughout the preseason, and even though they’ve lost to the Rams, 23-22 last weekend, the LAC look well.
QB Trey Lance plays good football during the preseason, and he has 296 passing yards with 2 touchdowns, and he ran 81 yards on the ground, for one TD.
Speaking of quarterbacks, Mac Jones didn’t do well during the preseason, despite his high pass completion rate – 17-for-23, 209 yards, 0 TDs, and 2 picks. He is injured and will not participate in this event.
News suggests that RB Christian McCaffrey is in excellent shape and that his recent practices have shown significant progress. According to the ESPN reports, he is in mid-season form right now, and it’s quite possible to see him on the field for a couple of snaps.
Chargers vs. 49ers Head to Head
Right now, the all-time series are tied, with each team having 8 wins apiece.
Chargers vs. 49ers Predictions
LAC will play hard, while on the other hand, we should see the hosts with Purdy and CMC on the field. Still, the home team looks as the favorite to us, and we will pick the Niners to win.
- Free NFL picks: 49ers win
NFL
More Predictions
NFL Week 9 Upsets: Commanders Nasty Underdogs, Cardinals and Raiders Defending the Spread
Week 9 of the 2026 NFL season features several situational spots where short underdogs hold tactical, scheduling, or matchup advantages. There aren’t as many choices as in previous rounds, but there’s still enough for us bettors to make some money. Here is one straight-up upset pick and two point-spread underdog picks, backed by key tactical […]
NFL Week 9 Player Props: Pitts to Score a TD, Flournoy Continues to Grow
NFL Week 9 player props are here. We’ve waited to see the situation regarding potential absences and injuries, and with game day just around the corner, it was time to unleash the best player prop picks for this round. We have three selections for our bettors, carefully picked and evaluated following a thorough process. After […]
Broncos vs. Panthers Week 9 Picks: Young’s Poor Protection Will Cost Carolina
Best bet: Broncos ATS pick: Broncos -2.5 Bet Broncos vs. Panthers at BetUS Denver Broncos (6-2) hit the road to face the Carolina Panthers (3-4) and continue their excellent run. The Panthers have been on the downhill lately and are under pressure to win this game and get back to the winning side. Stay with […]
Giants vs. Eagles Week 9 Picks: Rested Giants After a Win in Philly
Best bet: Giants ATS pick: Giants -3.5 Bet Giants vs. Eagles at BetUS NFC East is completely wild these days. The New York Giants (4-2-1) lead the group, while the Philadelphia Eagles (2-6) sit last. The home team is in huge trouble, having multiple stars out due to injuries. The Giants also have some absences, […]
Browns vs. Saints Week 9 Picks: Indoor Arena Will Create Problems for Cleveland
Best bet: Saints -1.5 Straight up pick: Saints moneyline Bet Cardinals vs Cowboys at BetUS Cleveland Browns (5-3) are still in the mix for the playoffs. However, they will need to win in New Orleans against the Saints (2-5). Browns are very light underdogs here, sitting at +100 before we started writing this article. We […]