Expert prediction
NFL Week 1: 49ers vs. Seahawks Preview, Odds, Picks (Sep 7)
- 49ers vs. Seahawks can be watched on FOX.
- San Francisco is a 2.5-point favorite.
- The total for this game is set at 44.5 points.
The 49ers and the Seahawks have much to hope for from this year. The first team has a squad with the potential for a deep playoff run, while the second is in the midst of a rebuild process.
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How to Watch
- When: Sunday, September 7, 4:05 pm ET
- Where: Lumen Field, Seattle, Washington
- How to Watch: FOX
49ers vs. Seahawks Odds
Game Preview
The Niners had a more or less quiet offseason, where they didn’t make too much of a fuss in free agency. On the other hand, it was noticeable that their draft revolved around defense, and that all their high picks were used on strengthening that part of the unit.
After losing to the Broncos in the opening preseason game, 30-9, they later beat both AFC West rivals, the Raiders, 22-19, and the Chargers, 30-23. Kyle Shanahan mostly used backups, and they really showed well.
The Seahawks turned a new leaf. They moved on from Geno Smith, and their new QB is Sam Darnold. Also, Tyler Lockett and DK Metcalf are out, while Cooper Kupp and several other veterans landed.
Head coach Mike Macdonald had started his tenure well, posting 10 wins and 7 losses last year, and is expected to stay on the same track, possibly to make a step forward if possible. After all, there are plenty of new players on the roster now.
49ers vs. Seahawks Head to Head
The Seahawks lead the series against the 49ers, with the Seahawks having 31 wins and the Niners having 23. Their last game was in 2024 when Seattle won on the road, 20-17.
49ers vs. Seahawks Predictions
The key here is that the Seahawks have plenty of new faces on the team, whereas the 49ers don’t. Their chemistry is at a higher level, and this should be a difference-maker in this event.
- Free NFL Picks: 49ers -2.5
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