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Expert prediction

NFL Week 1: Chiefs vs. Chargers Preview, Odds, Picks (Sep 5)

  • Nikola Velickovic
  • Aug 28, 2025 at 3:31 AM EDT
  • Chiefs vs. Chargers clash is set for Friday night in Sao Paulo.
  • Kansas City is a 3.5-point favorite.
  • The Chargers had the best defense in the NFL last year.

Another divisional rivalry will highlight the start of the season. Patrick Mahomes and the Chiefs visit Justin Herbert and the Chargers in LA.

If you are interested in more NFL odds and predictions, follow this link.

How to Watch

  • When: Friday, September 5, 8:00 pm ET
  • Where: Corinthians Arena, Sao Paulo, Brazil
  • How to Watch: YouTube

Chiefs vs. Chargers Odds

TeamMoneylineSpreadTotals
Chiefs-170-3.546.5
Chargers+145+3.546.5

Game Preview

The Chiefs had a season in which they oscillated too much, which is the reason why they haven’t reached the Super Bowl. Still, they have one of the best teams in the NFL and are among the top contenders for winning the Vince Lombardi trophy.

To be better this year, they’ll need to get TE Travis Kelce back on track. After deciding to marry Taylor Swift, the strong tight end should sort his stats out, as he had only 823 receiving yards last year, his worst since becoming a starter.

The Chargers’ defense allowed 17.7 points last year and was ranked No.1 in the NFL. Though, there were some changes this offseason that saw several players leaving LA, among them Joey Bosa.

On the flip side, RB Najee Harris landed in California, and knowing his characteristics, the LAC got one hard-working grinder who will constantly attack defensive lines.

Chiefs vs. Chargers Head to Head

The Chiefs hold an edge in the all-time series, with 71 wins, while the Chargers have 58 triumphs. One game saw a tie. Right now, Kansas City has 7 triumphs in a row over the Chiefs.

Last year, we saw their victories, 17-10 in LA and 19-17 at home.

Chiefs vs. Chargers Predictions

The over/under line is set at 46.5 points, and even though the Chargers lost plenty of their defensive stars, we are still going with under here. After all, Jim Harbaugh wouldn’t have let them go without having a proper replacement in position.

Free NFL picks: Under 46.5 points

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