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Expert prediction

NFL Week 1: Ravens vs. Bills Preview, Odds, Picks (Sep 7)

  • Nikola Velickovic
  • Sep 1, 2025 at 3:25 AM EDT
  • Ravens vs. Bills is the first Sunday Night Football of the season.
  • Bills are 1.5-point favorites.
  • This is a battle between two MVPs – Lamar Jackson and Josh Allen.

The Ravens ended their season against the Bills in the Divisional Round last January. The battles between Lamar and Allen are already epic, and this one should be nothing short of that.

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How to Watch

  • When: Sunday, September 7, 8:20 pm ET
  • Where: Highmark Stadium, Orchard Park, New York
  • How to Watch: NBC

Ravens vs. Bills Odds

TeamMoneylineSpreadTotals
Ravens-115+1.551.5
Bills-105-1.551.5

Game Preview

Ravens had all three wins during the preseason and were pretty confident. After beating the Colts 24-16 at home, they went on the road to trash the Cowboys, 31-13, and the Commanders, 30-3.

Baltimore’s offense was terrific last year, and with the addition of a star veteran WR DeAndre Hopkins, it should be better. Meanwhile, the defense got depth too, with CB Jaire Alexander landing and E Mike Green, who should contribute right away.

The Bills improved their defense during the summer. DE Joey Bosa is the biggest addition, while CB Tre’Davious White is back; however, the focus should be on the draft class. DT TJ Sanders and DE Landon Jackson are projected to enhance the defense, which often obliterated Allen’s offensive contribution last season.

Ravens vs. Bills Head to Head

It’s 7-6 for the Ravens after 13 games so far. Buffalo won the Divisional Round last season, 27-25 at home.

Ravens vs. Bills Predictions

Even if the weather is nice and everything, the Over/Under limit is still too high – 51.5 points. Yes, these are likely the top two offensive units in the AFC, but it is the first meeting of the season, and as we’ve seen, both the Ravens and the Bills have improved their defensive units. That’s why Under 51.5 points is our final decision here.

  • Free NFL picks: Under 51.5 points
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