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NFL Week 10: LA Rams vs. San Francisco 49ers Preview, Odds, Picks (Nov 9)

  • Nikola Velickovic
  • Nov 5, 2025 at 12:08 PM EST
  • Rams vs. 49ers total is 49.5 points.
  • The San Francisco 49ers beat the Rams 26-23 OT in Week 5.
  • Rams allow the 2nd fewest number of points per game, 15.9.

The big NFC West clash between the Rams and the Niners headlines Week 10. Whichever team wins here will have a huge chance of reaching the playoffs.

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How to Watch

  • When: Sunday, November 9, 4:25 pm ET
  • Where: Levi’s Stadium, San Francisco, California
  • How to Watch: FOX

Rams vs. 49ers Odds

TeamMoneylineSpreadTotals
Rams-210-4.549.5
49ers+175+4.549.5

Game Preview

The Rams are 6-2 coming into this event, also having the second-best defense in the NFL. They allow 15.9 points per game, and that’s a stat just a few notice. Defense isn’t getting credit as much as the offense.

As for the offense, Matt Stafford leads the No.1 passing crew in the league, averaging 258 passing yards per game. With 21 touchdown throws, he leads the league in that category, and besides that, he has just two intercepted passes.

The 49ers are battling various injuries and are still in the mix for winning the NFC West. Some say that WR Ricky Pearsall might be ready here, but QB Brock Purdy and others, like DE Bryce Huff, are out.

Niners were better than the Giants in New York last week, 34-24. Christian McCaffrey had 106 yards on the ground and a TD, while catching 67 receiving yards for one score as well. Jones was 19-for-24 for two touchdown passes and 235 yards through the air.

Rams vs. 49ers Head to Head

San Francisco was better in Week 5, 26-23 after overtime. The overall record in the series is 79-71-3 for the Niners.

Rams vs. 49ers Predictions

No matter their fighting spirit and grit, the 49ers are limited here. Rams are in excellent shape; they have no injuries and are improving their form on both ends of the field, which is why we have to pick their victory.

  • Free NFL Picks: Rams win
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