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Expert prediction

NFL Week 13: Arizona Cardinals vs. Tampa Bay Buccaneers Preview, Odds, Picks (Nov 30)

  • Nikola Velickovic
  • Nov 26, 2025 at 5:07 PM EST
  • Cardinals vs. Buccaneers Over/Under line is set at 44.5 points.
  • Baker Mayfield should play.
  • Tampa Bay has three straight losses.

The Tampa Bay Buccaneers have to win this one, otherwise, their playoff prospects will be in great danger.

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How to Watch

  • When: Sunday, November 30, 1 pm ET
  • Where: Raymond James Stadium, Tampa Bay, Florida
  • How to Watch: FOX

Cardinals vs. Buccaneers

TeamMoneylineSpreadTotals
Cardinals+115+2.543.5
Buccaneers-135-2.543.5

Game Preview

Even though the Cardinals are already planning the next season and their offseason moves, they won’t go down easily in the upcoming several games. Jacoby Brissett took over the starting QB position and is motivated to prove himself and earn a new contract. He plays decent football but has a 1-5 record.

Last weekend, Arizona lost at home to the Jaguars after overtime, 27-24. Their running game was awful, delivering only 55 yards on the ground, of which Brissett had 20.

The Buccaneers have lost 4 of their last 5 games. Because of this, the Panthers got just half a game behind them, narrowing Tampa Bay’s margin for error. It’s why this game is so important for Baker and the boys.

When mentioning Mayfield, his MRI came back negative, and it turns out that he just suffered a low-grade shoulder strain. He should be ready to play on Sunday. Baker had a great start to the season, but as time went on, he slowed down, and that’s when Tampa Bay’s results began to drop.

Cardinals vs. Buccaneers Head to Head

The all-time series is tied at 11-all. The last game played was in 2022 when the Buccaneers won 19-16 on the road after overtime.

Cardinals vs. Buccaneers Predictions

Tampa Bay is closer to winning here. Not just because they are in a tough spot and with their backs against the wall, but because, overall, they have a better team with more offensive solutions than their rivals. Both defenses are mediocre, but the Buccaneers’ offense is better.

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