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Expert prediction

NFL Week 16: LA Chargers vs. Dallas Cowboys Preview, Odds, Picks (Dec 21)

  • Nikola Velickovic
  • Dec 16, 2025 at 5:27 PM EST
  • Chargers vs. Cowboys odds favor Dallas at -125.
  • The TOTAL has gone UNDER in 4 of the Chargers’ last 5 games.
  • The TOTAL went OVER in 9 of Dallas’ last 11 matches.

The Dallas Cowboys have only theoretical chances in their playoff plan. And to leave that way, they have to win here. Meanwhile, the Chargers are in a fierce AFC playoff battle and can’t afford to lose here.

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How to Watch

  • When: Sunday, December 21, 1 pm ET
  • Where: AT&T Stadium, Arlington, Texas
  • How to Watch: FOX

Chargers vs. Cowboys Odds

TeamMoneylineSpreadTotals
Chargers+110+1.549.5
Cowboys-130-1.549.5

Game Preview

The LA Chargers are one of the best teams in the AFC, yet they have a very strong division, where they compete with the Broncos, who have two more wins. Still, the LAC is in the playoff zone and needs to continue winning to stay there.

They have the third-best pass defense in the NFL, allowing 174.4 yards through the air per game, and also allow the second-fewest number of total yards per event, just 279.1.

As for the Cowboys, recent back-to-back losses probably kicked them out of the playoff race. After losing to the Lions on the road, 44-30, they suffered a shock at home when the Vikings took the win in Texas, 34-26.

Again, the defense was terrible, allowing 34 points and forcing just one turnover. And for the record, they didn’t manage to record a sack on JJ McCarthy. Dak Prescott threw for 294 passing yards without a touchdown or an interception.

Chargers vs. Cowboys Head to Head

Dallas leads the all-time series 8-5, and has two wins in a row, the most recent in 2023, 20-17 on the road.

Chargers vs. Cowboys Predictions

We pick the Chargers here. Their defense is way better, and the attack is pretty much equal to the Cowboys’. Plus, even though hosts have the home-court edge, they won’t be as motivated as the guests.

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