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Expert prediction

NFL Week 2: Eagles vs. Chiefs Preview, Odds, Picks (Sep 14)

  • Nikola Velickovic
  • Sep 9, 2025 at 11:24 AM EDT
  • Eagles vs. Chiefs matchup highlighted two of the last three Super Bowls.
  • The Chiefs lost last week to the Chargers in Sao Paulo, 27-21.
  • Philadelphia Eagles were better than the Cowboys on the opening night, 24-20.

The record in the Super Bowls is tied, 1-1, but the Eagles had the last laugh, beating Mahomes and the boys in New Orleans a few months ago.

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How to Watch

  • When: Sunday, September 14, 4:25 pm ET
  • Where: Arrowhead Stadium, Kansas City, Missouri
  • How to Watch: FOX

Eagles vs. Chiefs Odds

TeamMoneylineSpreadTotals
Eagles-115-1.546.5
Chiefs-105+1.546.5

Game Preview

Jalen Hurts dominated the Cowboys in the opening game of the year. He ran for 62 yards and two touchdowns, though, throwing only 152 yards, but without any turnovers.

If it weren’t for Philly’s running, which generated 158 yards, this would be a problematic game for the hosts, because their top receivers didn’t show up – A.J. Brown 8 yards and DeVonta Smith 16.

The Chiefs traveled to Sao Paulo, where they lost to the division rivals, the LA Chargers, 27-21. Mahomes gave everything he had, throwing for 258 yards and one TD, and also running for 57 yards and another touchdown.

Kansas City didn’t have too many options in its attack, particularly on the ground. Without Mahomes, they had only 41 rushing yards, which is too low. Especially when you have the best NFL defense across the scrimmage line.

Eagles vs. Chiefs Head to Head

So far, there have been 12 games between these two sides, and the result is tied at 6-6. Eagles have won the last two in 2023 and last year’s Super Bowl.

Eagles vs. Chiefs Predictions

This is a big-time game between two of the best teams in the NFL. Even though they looked a bit sleepy in the opening round, we expect to see them fully prepared for this event. Since both teams prefer to break the rivals through offense, our pick will be over 46.5 points.

Free NFL picks: Over 46.5 points

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