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Expert prediction

NFL Week 3: Colts vs. Titans Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 15, 2025 at 9:41 AM EDT
  • Colts vs. Titans division games will impact the AFC South standings a lot.
  • Daniel Jones has 3 rushing and 2 passing touchdowns.
  • No.1 pick, QB Cam Ward, still struggles to gain consistency.

A win in this one is worth double, because this is an AFC South rivalry. And each triumph over a division rival is worth gold.

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How to Watch

  • When: Sunday, September 21, 1 pm ET
  • Where: Nissan Stadium, Nashville, Tennessee
  • How to Watch: CBS

Colts vs. Titans Odds

TeamMoneylineSpreadTotals
Colts-185-3.543.5
Titans+155+3.543.5

Game Preview

The Colts are 2 for 2 at home and now head for the first road game of the season. After beating the Dolphins, 33-8, they would squeeze out a victory against the Denver Broncos, 29-28. Despite struggling on the offensive side in the end, the rivals were sloppy, too, so Indianapolis snatched a win.

Daniel Jones threw for 316 yards against the Broncos, while RB Jonathan Taylor ran for 165 yards, without a TD, yet was over-dominant on the field. Jones delivered the sole score on the ground.

For one half, the Titans looked capable of going toe-to-toe with the Rams. After leading 13-10 at the half, the final score was 33-19 for the LA guests. Cam Ward was 19-for-33, with one touchdown, and 175 passing yards. He would fumble and lose one ball too.

Tonny Pollard had a solid game, rushing for 92 yards on 20 carries. But others weren’t at the same level, and the whole team added 17 yards, which is the reason for this defeat.

Colts vs. Titans Head to Head

The overall score in the all-time series is 39-22 for the Colts. Last year, Indianapolis won on both occasions, 20-17 on the road and 38-30 at home.

Colts vs. Titans Predictions

Indianapolis has a nice chance to take a road win here and also beat a division rival. Titans are still searching for themselves, and our pick for this contest is the Colts to triumph.

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