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Expert prediction

NFL Week 4: Colts vs. Rams Preview, Odds, Picks (Sep 28)

  • Nikola Velickovic
  • Sep 24, 2025 at 5:16 AM EDT
  • Colts vs. Rams total is 49.5 points.
  • Indianapolis Colts are the 2nd-best offense in the league.
  • Rams lost to the Eagles in Philly, 33-26.

These two teams are highly potent on the offensive side; therefore, this should be an interesting game at SoFi Stadium this Sunday afternoon.

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How to Watch

  • When: Sunday, September 28, 4:05 pm ET
  • Where: SoFi Stadium, Inglewood, California
  • How to Watch: FOX

Colts vs. Rams Odds

TeamMoneylineSpreadTotals
Colts+165+3.549.5
Rams-195-3.549.5

Game Preview

The Colts are the second-best offense in the league with 103 points scored. They average 418.7 yards per game, yet on the other side, allow just 272.3 yards from scrimmage. RB Jonathan Taylor is unstoppable, and it’s no wonder to see Indy generating 153.3 rushing yards per game.

Titans were their last victims, 41-20 in Nashville, where Taylor had 3 touchdowns. Arguably, the best running back in the league ran for 102 yards, too. Daniel Jones threw for 228 yards and one TD.

The Rams had everything in their hands in Philly, yet they eventually lost 33-26, wasting a good chance to secure a big road win. LAR are also very good on both ends, generating 363.7 yards from scrimmage, which ranks No. 5 in the NFL, and allowing 268.3, also the fifth-best only on defense.

Matt Stafford threw for 739 passing yards, 5 TDs, and two picks, and his top target was Puka Nacua, who has 333 receiving yards on 29 receptions.

Colts vs. Rams Head to Head

The overall score between these two sides is 23-22-2, but the Rams posted the last four wins. Most recent in 2023, 29-23 on the road.

Colts vs. Rams Predictions

The Over/Under line for this game is 49.5 points, and our pick is over. Why? Even though both teams have solid defenses, their offensive potential exceeds them, and this should be a high-scoring event.

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