Expert prediction
NFL Week 6: Cardinals vs. Colts Preview, Odds, Picks (Oct 12)
- Cardinals vs. Colts total is set at 46.5 points.
- The Indianapolis Colts are the No. 2 offense in the NFL, averaging 32.6 points per game.
- Arizona Cardinals have 3 straight losses.
This is a huge test for the Cardinals, who have lost their last three games by a combined margin of 5 points. Though luck for Arizona, which is about to be even tougher, as they face the Indianapolis Colts on the road.
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How to Watch
- When: Sunday, October 12, 1 am ET
- Where: Lucas Oil Stadium, Indianapolis, Indiana
- How to Watch: FOX
Cardinals vs. Colts Odds
Game Preview
The Arizona Cardinals (2-3) opened the season with a 2-0 record but have experienced three straight losses, all of which have been extremely narrow. The most recent was against the Tennessee Titans, 22-21. Just to note here that the Cards had a 21-3 lead.
This game could have long-standing consequences for Arizona, as it could kill the morale of the unit. The team ran for 168 yards, with all three of their TDs coming on the ground, yet when it mattered the most, the Cards froze and lost.
Indianapolis Colts lost to the Rams on the road yet bounced back quickly, smashing the Raiders, 40-8. RB Jonathan Taylor has had 3 rushing touchdowns in just 66 yards on the ground, while QB Daniel Jones had 212 passing yards with 2 touchdown passes.
Colts’ secondary picked off Geno Smith twice, effectively shutting down the Raiders’ pass game early on. There’s one more thing that is not popularized in the media – Indianapolis has the 3rd-best defense in the FL, allowing just 17.8 points per game.
Cardinals vs. Colts Head to Head
The all-time series is tied right now, 9-9. The last game was in 2021, when the Colts beat the Cardinals in Glendale, 22-16.
Cardinals vs. Colts Predictions
Arizona is in trouble, and a trip to Indianapolis comes at the worst possible moment. They won’t give up, that’s for sure, but on the other side, the Colts’ offensive power is just too much for the Cardinals. Especially at Lucas Oil Stadium.
- Free NFL Picks: Colts Win
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