Expert prediction
NFL Week 9: 49ers vs. Giants Preview, Odds, Picks (Nov 2)
- Nikola Velickovic
- Oct 30, 2025 at 4:22 AM EDT
- 49ers vs. Giants game is a battle of injury-banged teams.
- Cam Skattebo ended his season due to multiple injuries.
- Bryce Huff and Dee Winters will probably miss this one.
The battle between two teams that struggle with numerous injuries. This could be a tricky one due to all the absences, so stay tuned to see some NFL tips.
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How to Watch
- When: Sunday, November 2, 1 pm ET
- Where: MetLife Stadium, East Rutherford, New York
- How to Watch: CBS
49ers vs. Giants Odds
Game Preview
Neither DE Bryce Huff nor LB Dee Winters has participated in training this week, and the chances of seeing them play in this event are rapidly diminishing. Though the Niners won’t lament over that, but get out and battle, as Kyle Shanahan always has some solution.
Last weekend, they suffered a nasty loss to the Texans in Houston, 26-15. It was one of their worst game of the year, especially for Christian McCaffrey, who had only 25 rushing yards. Overall, the 49ers had 48 yards on the ground, and that was something that limited their offense heavily.
Next stop: NY 🗽 pic.twitter.com/ISEvWEU0wn
— San Francisco 49ers (@49ers) October 30, 2025
After miraculously dropping a win over the Broncos two weeks ago, the Giants now experienced another devastating blow. It’s not about a 38-20 loss to the Eagles, but about RB Cam Skattebo ending his season due to injuries.
Knowing that he was the motor of the offense, this will be a massive loss for the Giants, who already lost WR Malik Nabers. Meanwhile, LB Brian Burns continues his NFL DPOY campaign, having 10 sacks at the moment. One was against the Eagles.
49ers vs. Giants Head to Head
The Niners and Giants met 43 times in the past, and the current record is barely on the 49ers’ side, 22-21. They had some nasty playoff contests during the ’80s and the early ’90s.
49ers vs. Giants Predictions
Losing Skattebo will heavily disrupt the Giants’ offense, and no matter the situation among the 49ers, this is something Dart and the boys can’t cover. San Francisco has a deeper roster and is already accustomed to playing without its best players, so we bet on the guests from California to win this event.
- Free NFL Picks: 49ers Win
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