Expert prediction
Premier League: Arsenal vs. Man City Picks, Odds, and Preview (Sep 21)
- Alex Dudley
- Sep 18, 2025 at 5:06 AM EDT
Pick rationale
Analysis & key factors
Two rivals in the Premier League title race lock horns at the Emirates Stadium this weekend. Arsenal and Man City will both be looking to close the gap on Liverpool at the summit, while a defeat for either could be damaging to their championship prospects. You can find the odds and picks here.
How To Watch
- When: Sunday, September 21, 2025, at 11:30 AM ET
- Where: Emirates Stadium, London, England
- How To Watch: NBC
Arsenal vs. Man City Odds
Head-to-Head Record
Arsenal have recorded victories in two of their last four league meetings with Man City, and they have avoided defeat in all fixtures over that period. The Gunners could win back-to-back matches against City for the first time since December 2015.
Match Preview
Man City got their title challenge back on track after recent defeats by beating Man United impressively in the derby at the Etihad. Pep Guardiola’s side looked sharper at both ends of the field in that success, with Erling Haaland netting a brace.
However, City will have a reduced amount of time to prepare for this clash due to their Champions League match with Napoli on Thursday. That could be a worry, as City have lost five of their last seven fixtures in the Premier League following a midweek European outing.
READ More: USA Today 301 Picks, Odds, and Preview (Sep 21)
Arsenal’s only blip so far this season was suffered at Anfield at the hands of Liverpool, but Mikel Arteta’s side made it three wins from four with a straightforward success against Nottingham Forest last Saturday. Summer signing Martin Zubimendi was the star of the show after netting twice.
The Gunners have won their last three home matches in the competition by a 9-0 scoreline, and they could win four successive matches to nil for the first time since December 2021. But, there could still be an overreliance on set pieces for the Gunners, as they are still stuttering to create chances from open play.
Arsenal vs. Man City Picks
There are still doubts surrounding City’s and Arsenal’s title credentials, and this weekend’s clash could go a long way to determining the pecking order. City were much better against United last weekend, and we could see them building on that win against the Gunners.
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