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EPL Matchday 5 Predictions: Best Bets & Weekend Picks (Sep 18-20)

  • Alex Dudley
  • Sep 18, 2026 at 4:29 AM EDT

Pick rationale

Analysis & key factors

The final round of Premier League fixtures before the September international break is staged this weekend.

Fascinating matchups will see Chelsea take on Brentford, while Arsenal and Manchester City aim to extend their perfect league records when they clash with Brighton and Sunderland, respectively. High-pressure encounters include Aston Villa’s trip to winless Tottenham, while Michael Carrick will be hoping to ease the pressure on his shoulders when Man United travel to Fulham.

You can find our best bets and weekend picks for this weekend’s EPL action here, including a best bet and parlay predictions.

EPL Best Bets & Top Value Picks

  • Best Pick: Man City (vs. Sunderland)
  • Best Both Teams to Score (BTTS): Brighton vs. Arsenal
  • Best Value Over/Under: Tottenham vs. Aston Villa Under 3.5 Goals

ALSO SEE: Presidents Cup Picks, Odds & Betting Preview (Sep 24-27)


Key Fixture Breakdown & Predictions

Tottenham vs. Aston Villa Prediction & Odds

Kickoff: Saturday, September 19 | 7:30 AM ET  | Tottenham Hotspur Stadium, London

Match Preview

An early six-pointer in the Premier League is set for the Tottenham Hotspur Stadium on Saturday, as winless rivals Spurs and Aston Villa collide in North London. Both sides have endured offensive setbacks throughout the campaign, with a collective tally of a single goal scored between the Villains and Tottenham in eight league outings.

That obviously supports the chances of a low-scoring encounter this weekend. Villa’s record against Spurs is also incredibly eye-catching, as the team from the West Midlands have avoided defeat in four of the last five head-to-heads. A cagey draw could appease both managers on Saturday.

Bournemouth vs. Liverpool Prediction & Odds

Kickoff: Sunday, September 20 | 9:00 AM ET  | Vitality Stadium, Bournemouth

Match Preview

Confidence within the Bournemouth camp will be sky-high following a first-ever win in Europe on Thursday evening. However, they will have limited time to recover ahead of the visit from former boss Andoni Iraola’s Liverpool on Sunday.

The Reds have recorded wins in two of their last three in all competitions, but league consistency continues to be an issue, with just one win recorded in four outings. The head-to-head trends support the chances of the visitors this weekend, as Liverpool have won 18 of the last 22 overall meetings, which includes nine wins in their last 12 at the Vitality Stadium.

Fulham vs. Man United Prediction & Odds

Kickoff: Sunday, September 20 | 11:30 AM ET  | Craven Cottage, London

Match Preview

Winless Fulham host struggling Man United in the final clash of the EPL weekend. The Red Devils started the campaign among the likely dangers to Man City and Arsenal in the title odds, but Michael Carrick has endured a damaging start to his tenure, highlighted by back-to-back defeats against City and Brighton this week.

The Cottagers were much better defensively in their recent 0-0 draw against Liverpool, while they have scored five goals in their previous three in all competitions. Another miserable defensive display could hinder United’s progression this weekend.


EPL Best Parlay Pick

The best value when making EPL betting selections this weekend could come in the form of a parlay. A high-scoring clash between Brighton and Arsenal looks like a standout leg based on the attacking output of both sides, while Nottingham Forest’s excellent defensive record could be key in a low-scoring clash with Coventry.

Newcastle and Man City are standout moneyline angles against Hull and Sunderland, respectively. The five-team parlay is rounded off by over 2.5 goals in Fulham vs. Man United.


EPL Matchday 5 Schedule & Picks

DateTimeFixtureEPL Pick
Fri, Sep 183:00 PM ETBrentford vs. ChelseaBTTS (Both Teams to Score)
Sat, Sep 197:30 AM ETTottenham vs. Aston VillaUnder 3.5 Goals
Sat, Sep 1910:00 AM ETEverton vs. IpswichEverton
Sat, Sep 1910:00 AM ETBrighton vs. ArsenalOver 2.5 Goals
Sat, Sep 1910:00 AM ETNewcastle vs. HullUnder 3.5 Goals
Sat, Sep 1912:30 PM ETNottingham Forest vs. CoventryNottingham Forest
Sun, Sep 209:00 AM ETBournemouth vs. LiverpoolLiverpool
Sun, Sep 209:00 AM ETMan City vs. SunderlandMan City
Sun, Sep 209:00 AM ETLeeds vs. Crystal PalaceLeeds
Sun, Sep 2011:30 AM ETFulham vs. Man UnitedBTTS (Both Teams to Score

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