EPL Matchday 6 Predictions: Best Bets & Weekend Picks (Oct 10-12)

The Premier League returns following the international break this weekend, with marquee fixtures set for Saturday and Sunday. Man City will be in action for the first time since being found guilty of breaching EPL rules when they travel to Anfield. Meanwhile, Man United and Tottenham collide at Old Trafford, with both teams aiming to reignite their form after slow starts to the 2026-27 season. You can find our best selections for every matchup, a parlay bet, and our best EPL picks for MD6 here.  

EPL Best Bets & Top Value Picks

• Best Pick: Arsenal (vs. Leeds United)
• Best Both Teams to Score (BTTS): Liverpool vs. Man City
• Best Value Over/Under: Man United vs. Tottenham (Over 2.5 Goals)

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EPL Matchday 6 Schedule & Picks For All Matches

Date	Kick-Off	Matchup	EPL Picks
Sat, Oct 10	7:30 AM ET	Arsenal vs. Leeds United	Arsenal & Over 2.5 Goals
Sat, Oct 10	10:00 AM ET	Aston Villa vs. Brentford	BTTS
Sat, Oct 10	10:00 AM ET	Ipswich vs. Fulham	Under 2.5 Goals
Sat, Oct 10	10:00 AM ET	Chelsea vs. Bournemouth	Chelsea
Sat, Oct 10	10:00 AM ET	Sunderland vs. Brighton	Brighton
Sat, Oct 10	12:30 PM ET	Man United vs. Tottenham	SEE PICKS HERE
Sun, Oct 11	9:00 AM ET	Crystal Palace vs. Nottingham Forest	The Draw
Sun, Oct 11	9:00 AM ET	Hull vs. Everton	Everton
Sun, Oct 11	11:30 AM ET	Liverpool vs. Man City	SEE PICKS HERE
Mon, Oct 12	3:00 PM ET	Coventry vs. Newcastle	Newcastle

ALSO SEE: Breeders’ Cup Classic Picks, Odds, Leading Contenders, Betting Insights & Analysis

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Key Fixture Breakdown & Predictions

Arsenal vs. Leeds Prediction & Odds

Kickoff: Saturday, October 10 | 7:30 AM ET  | Emirates Stadium, London

Match Preview

Mikel Arteta has had a long time to dwell on Arsenal’s heavy 3-0 defeat against Brighton before the international break, which was arguably the team’s worst performance since the start of last season.

It will be far from a gentle reintroduction to the league campaign this weekend, as Leeds have been one of the eye-catching teams in the English top-flight this season. Daniel Farke’s side have avoided defeat in all five fixtures, conceding no more than once in any match that they have played.

However, Arsenal’s dominant head-to-head advantage ensures that the Gunners hold the advantage. Leeds have won just twice in their last 17 trips to Arsenal, with the hosts winning 14 over the same period.

• Best Bet: Arsenal (-262)

Chelsea vs. Bournemouth Prediction & Odds

Kickoff: Saturday, October 10 | 10:00 AM ET  | Stamford Bridge, London

Match Preview

For the first time since taking the Chelsea job, Xabi Alonso will have questions to answer this weekend. The Blues have failed to win in their last three, and their last match saw them thumped 3-0 by Brentford.

It has also been a rocky start to life in the EPL for Marco Rose, as Bournemouth sit 17^th in the standings after failing to win in five. However, their performances have been better than the bare results suggest, having thrown away leads in four of their fixtures.

However, Chelsea’s dominant record in this fixture is notable, having won six of their last eleven home matches against the Cherries. A return to winning form should be expected by the Blues.

• Best Bet: Chelsea (-136)

Coventry vs. Newcastle Prediction & Odds

Kickoff: Monday, October 12 | 3:00 PM ET  | Coventry Building Society Arena, Coventry

Match Preview

The Premier League weekend rounds off on Monday, as Newcastle United travel to newly promoted Coventry City. The international break may have come at a bad time for the Sky Blues, as they would have been riding high following a first top-flight win in over 20 years against Nottingham Forest.

In contrast, it likely came at the perfect time for the Magpies after dropping points against Bournemouth and Leeds.

Newcastle’s weak defensive record will give Coventry a chance on Monday, as they have allowed seven goals in their previous three. This could ensure that there is value in the away win and BTTS at the Coventry Building Society Arena.

• Best Bet: Newcastle (+117)

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EPL Best Parlay Picks This Weekend

The best value when making EPL picks comes in the form of combining selections to create a parlay. Wins for Newcastle and Arsenal will rank as standout selections this weekend, while a Chelsea win and a Draw in Liverpool vs. Man City will boost the odds. Over 2.5 goals in Man United vs. Tottenham rounds off our five-leg EPL parlay.

• Best EPL Parlay Bet: Arsenal, Chelsea, and Newcastle to Win, Over 2.5 Goals in Man United vs. Tottenham and a Draw in Liverpool vs. Man City (+3465)

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How to Bet On EPL Matches This Weekend

These are the best sportsbooks for U.S. bettors to place wagers on the EPL today:

Sportsbook ratings

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