Expert prediction
Cincinnati Open: Frances Tiafoe vs. Holger Rune Picks, Odds, and Preview (Aug 13)
Pick rationale
Analysis & key factors
The round of 16 at the Cincinnati Open gets underway on Wednesday, August 13, as some of the major hopes for the U.S. Open will be hoping to build momentum. American star Frances Tiafoe will face a tough challenge against Norwegian Holger Rune, and you can find the odds and picks here.
How To Watch
- When: Wednesday, August 13, 2025 at TBD
- Where: Lindner Family Tennis Center, Cincinnati, Ohio
- How To Watch: Tennis Channel
Frances Tiafoe vs. Holger Rune Odds
Head-to-Head Record
Surprisingly, this will only be the second ever meeting between Tiafoe and Rune. The only previous encounter was won in three sets by Tiafoe in the semi-final stage of Indian Wells in 2024.
Match Preview
Frances Tiafoe will once again be among the leading American hopes at the US Open this year. At the Cincinnati Open, he will be aiming to build momentum ahead of the competition getting underway at Flushing Meadows.
Tiafoe has been in excellent form in Ohio so far, winning each of his opening two round matches without dropping a set. His spot in the round of 16 was secured on Monday after powering past 20th seed Ugo Humbert. The American has dominated on first serves, winning 76% of the points, and he only allowed his French rival two break point opportunities.
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Holger Rune is still widely considered to be one of the best young players on the ATP Tour. He has already shown his ability on hard courts in the U.S. this calendar year after reaching the final at Indian Wells. However, his form on the surface is largely inconsistent, as reflected after a first-round exit at the US Open last year.
Rune has required tie-breaks in three of the four games that he has played at the Cincinnati Open this year, but he still showed excellent character to get the better of Alex Michelsen in the previous round. However, despite winning 82% of the points on his first serve, he recorded a relatively low tally of just 68 winners.
Frances Tiafoe vs. Holger Rune Picks
Rune’s performances on the hard surface mean that it is hard to say with any confidence whether he enjoys the terrain. Therefore, it could be worth siding with the red-hot Tiafoe, maintaining his recent solid form in Ohio on Wednesday.
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