US Open: Venus Williams vs. Karolina Muchova Picks, Odds, and Preview (Aug 25)

The legendary Venus Williams will be one of the standout names in action on the second day at the US Open in 2025. Williams will be aiming to upset the odds when she takes on Karolina Muchova at Arthur Ashe Stadium. But, can the legendary American roll back the years? Find the odds and our picks here.

---

How To Watch

• When: Monday, August 25, 2025, at 7:00 PM ET
• Where: USTA Billie Jean King National Tennis Center
• How To Watch: ESPN

---

Venus Williams vs. Karolina Muchova Odds

Player	Odds
Karolina Muchova	-1100
Venus Williams	+709

---

Head-to-Head Record

This week’s clash between Williams and Muchova will be the second time that the stars have collided. The first meeting came back in 2020, with Muchova winning at the US Open in straight sets.

---

Match Preview

There has been the welcome sight of Venus Williams back on a tennis court this summer, and the American will be chasing an 80th victory at the US Open on Monday. Williams gained a famous win at the Citi Open in July, but she has suffered successive defeats in straight sets in her last two.

The legendary 48-year-old is a seven-time Grand Slam champion, but the US Open marks her return to the top-tier events for the first time since suffering a first-round elimination at Flushing Meadows in 2023. In fact, Williams hasn’t progressed further than the third round in any major since reaching the final four at the US Open in 2017.

READ More: Cook Out 400 Picks, Odds, and Preview (Aug 16)

Karolina Muchova will play the role of villain in the matchup this week, as she bids to upset the hometown hero. The Czech player reached the round of 16 at the National Bank Open in August, before suffering an early exit at the Cincinnati Masters a few weeks ago.

However, the 29-year-old currently sits in a lofty position of 12th in the world rankings, and she has typically excelled at the US Open in recent years. Muchova has reached the semi-finals in each of the last two years, and her consistency in Grand Slams is reflected by the fact that she has reached the final four in three of the four majors.

---

Venus Williams vs. Karolina Muchova Picks

Williams hasn’t played much tennis this year, and that would be an obvious concern ahead of this clash. It will be a welcome sight to see her back in action at Flushing Meadows, but she is likely to come up short against a player with genuine hopes of winning the major in New York.

Free Picks:

• Karolina Muchova (-1100)